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  • Chemistry  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Transport phenomena and kinetics in an extravascular bioartificial pancreas (1996)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 42 (1996), S. 2668-2682 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A bioartificial pancreas, consisting of immobilized islets encapsulated within hollow fibers, is investigated as an alternative treatment for insulin-dependent diabetes. A mathematical model is developed to determine whether this configuration of the bioartificial pancreas can yield an insulin response to a glucose challenge with the appropriate dynamics in diabetic humans. The model consists of the 2-D mass-conservation equations for glucose and insulin within the hollow fiber and capillaries. The equations contain terms for insulin-production kinetics by porcine islets and glucose-consumption kinetics. The boundary conditions account for transport resistances of the fiber membrane, the tissue surrounding the implant, and a thin film within the capillaries. The equations are coupled to a pharmacokinetic model of the circulatory system. The calculations show that an optimized design with this configuration will be feasible for human use and requires a total volume of 4.6 mL to reach the target insulin concentration in the bloodstream following a glucose challenge. The parameters and processes controlling the system performance are discussed.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690420928
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Wall-cooled fixed-bed reactors: Parametric sensitivity as a design criterion (1989)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 35 (1989), S. 287-292 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Multitubular reactors of the heat exchanger type are commonly used to carry out highly exothermic reactions. Two of the main goals, when designing this type of reactor, are to guarantee a safe operation and to minimize the reactor length. Therefore, these concepts are used here as criteria for comparing the performance of the three most common cooling-medium flow arrangements. The analysis of the parametric sensitivity behavior, as well as that of some related measures, indicates that, at least from the steady-state standpoint, the cocurrent arrangement should be considered the most attractive alternative.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690350213
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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