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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Biomaterials 6 (1995), S. 225-230 
    ISSN: 1045-4861
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The distal migration of polyethylene wear debris appears to be a major cause of loosening and osteolysis of cementless total hip arthroplasties. The use of modern cementing techniques, circumferential porous or hydroxyapatite (HA) coating has been advocated as a means of preventing access of the particles to the bone-implant interface. The purpose of this study was to compare the ability of different methods of implant fixation to prevent wear debris migration. Three each of smooth, porous-coated, HA-coated, and cemented hemiarthroplasties were implanted in the right hip of 12 dogs. Polyethylene particles were injected into the hip once a month for 4 months and then the femurs were sectioned. The percentage bone ingrowth was 8% for the smooth, 38% for the porous, and 83% for the HA-coated sections. Infiltration of the interface membrane by histiocytes containing polyethylene particles, and endosteal scalloping or osteolysis were found on all sections of the smooth prostheses. No particles or osteolysis were found on any sections of the other three types of prostheses. Capsular and lymph node sections from all dogs revealed histiocytic infiltration with numerous polyethylene particles present. It is concluded that the use of cement, porous, or HA coating prevents or delays access of the polyethylene wear debris to the bone-implant interface. No one of these methods of fixation proved more advantageous in the 5-month limit of this study. © 1995 John Wiley & Sons, Inc.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 569-584 
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Biochemical studies on mode of action enable the chemist to optimize biologically active chemical structures. As a case study we describe the optimization process of fungicides inhibiting sterol biosynthesis. The spiroketalamines obtained represent new chemicals with various modes of action on sterol biosynthesis. These examples demonstrate that biochemixal studies allow directed pesticide design. The value of biochemistry in pesticide discovery has to be seen in a stepwise optimization rather than in “de-novo”-design.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 11 (1997), S. 523-538 
    ISSN: 0268-2605
    Keywords: silicon-modified ; carbohydrate ; surfactant ; Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ionic siloxanyl-modified carbohydrate surfactants have been synthesized by alkylation/esterification of precursors containing tertiary amino functions. Depending on the reaction strategy, the siloxanyl moiety is part of the alkylating agent or the substrate. Polyhydroxylated tertiary amines can be quaternized by siloxanyl-modified chloroacetic acid esters or epoxysiloxanes in the presence of glacial acetic acid. The esterification of tertiary amines bearing carbohydrate and siloxanyl subunits by cyclic acid anhydrides yields, after neutralization, carboxylate salts. The reaction of hydroxyl groups and sulfamic acid leads to sulfates. The new substances were characterized by means of 13C NMR spectroscopy, gas chromatography, elemental analysis and their solubility profile. © 1997 John Wiley & Sons, Ltd.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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