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  • 1
    Electronic Resource
    Electronic Resource
    Cybernetic modeling of microbial growth on multiple substrates (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 26 (1984), S. 1272-1281 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The internal regulatory processes, which underlie a variety of behavior in microbial growth on multiple substrates, are viewed as a manifestation of an invariant strategy to optimize some goal of the cells. A goal-seeking or cybernetic model is proposed here, with the optimization obased on a short-term perspective of response to the environment. The model parameters are determined from the growth data on single substrates. The model predicts the entire range of microbial growth behavior on multiple substrates from simultaneous utilization of all sugars to sequential utilization with pronounced diauxic lags. It is shown to predict the many variations of the diauxic phenomenon in different growth conditions. The transients in continuous culture growth on mixed substrates caused by varying the feed strategies are easily simulated by this model. The framework of this model can be applied to batch or continuous culture growth of many bacteria on different combinations of substrates.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260261103
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  • 2
    Electronic Resource
    Electronic Resource
    Revised enzyme synthesis rate expression in cybernetic models of bacterial growth (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 31 (1988), S. 41-43 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A revised enzyme synthesis rate expression for cybernetic models of bacterial growth is presented. The rate expression, which is comprised of inducible and constitutive contributions, provides for a basal enzyme level that is necessary to predict certain types of commonly observed continuous culture transients. The response of a continuous culture to a step change in feed stream composition is simulated using both the old and new formulations, and the ramifications for the “matching-law” formulation are discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260310107
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  • 3
    Electronic Resource
    Electronic Resource
    Investigation of bacterial growth on mixed substrates: Experimental evaluation of cybernetic models (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 28 (1986), S. 1044-1055 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Cybernetic models, developed earlier by the authors, have been evaluated experimentally for the growth of Klebsiella oxytoca in batch cultures using mixed substrates from glucose, xylose, arabinose, lactose, and fructose. Based entirely on information procured from batch growth on single substrates, the models accurately predict without further parameter fitting, diauxic growth on mixed substrates, automatically predicting the order in which the substrates are consumed. Even triauxic growth on a mixture of glucose, xylose, and lactose is predicted by the model based on single substrate data. Growth on glucose-fructose mixtures appears to need a slightly modified strategy for cybernetic variables.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260280715
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  • 4
    Electronic Resource
    Electronic Resource
    Toward a self-similar theory of microbial populations (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 43 (1994), S. 138-148 
    Details
    ISSN: 0006-3592
    Keywords: cell population ; cytometry ; segregated model ; cytometry ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A fresh quest is made of segregated cell models of microbial populations with a view to determine whether the multivarite distribution of physiological states, during transient growth, can attain self-similar forms (i.e., become time invariant) when each physiological state variable is scaled with respect to its population average. Such self-similar growth situations are believed to be more general than those of balanced growth. The conditions under which self-similarity is possible are investigated. Thus conditions are stipulated on the synthesis rates of different physiological entities, cell division rate, and the partitioning of the parent cell's components among the daughter cells (assuming binary division) in order for self-similar growth to be attained. Subject to the attainment of self-similar growth, it is shown that cytometric data can be analyzed systematically to determine how the rates of syntheses of various biochemical entities and cell division rates vary with the physiological entities that are measured. Inverse problems, represented by algebraic systems, are identified which will potentially allow flow cytometric data to be inverted to yield quantitative information on the absolute rates of cellular growth and reproductory processes as a function of the cell states chosen for measurement. It is suggested that the methods become more effective when cytometry can be used to make direct observations on dividing cells so that the number of unknowns in the inverse problem can be reduced, thus facilitating its more complete solution. Preliminary analysis of cytometric data obtained in the literature show promise of self-similarity and thus the possibility of application of the methods discussed here. © 1994 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260430206
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of dispersed-phase systems: Fresh perspective (1995)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 41 (1995), S. 35-44 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Dispersed-phase systems are analyzed with a fresh perspective where the volume fraction of the dispersed phase is emphasized, not particle numbers as in population balance. Such volume fraction balances are more pertinent to engineering because they deal with the amount of the dispersed phase relative to that of the continuous phase. Although it is easy to make detailed volume fraction balances directly or from population balance, many interesting features are identified here with balance equations in terms of volume fraction, which simply characterize the dispersion process and structure the resulting equation. They lead to equivalent “single-particle” (comprising the entire dispersed phase) processes which can be simulated with great simplicity allowing rapid calculation of quantities associated with the dispersed phase and dispersion. The techniques can solve an inverse problem for mass-transfer coefficients of individual droplets from (simulated) measurements of the bivariate distribution of drop size and concentration of a transferring solute. Such inverse problem method is important in developing experimental techniques techniques to measure multivariate population distributions such as those of Bae and Tavlarides (1989) and of flow cytometry.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690410105
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of mass transfer on droplet breakup in stirred liquid-liquid dispersions (1987)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 33 (1987), S. 1899-1902 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690331118
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  • 7
    Electronic Resource
    Electronic Resource
    Stochastic models of algal photosynthesis in turbulent channel flow (1977)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 23 (1977), S. 794-804 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Models have been formulated and analyzed for photosynthesis by algae in turbulent, channel flow. Analytical and computational for results for different stochastic, kinematic models of algal motion have been obtained for two different rate mechanisms. The results indicate that turbulent mixing can achieve an increase in the rates and efficiencies of photosynthesis by realizing the intermittency effects. Optimum levels of turbulence are shown to exist in turbulent channel flow for the mass cultivation of algae. The methodology of this paper is relevant to photochemical reactions in general.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690230604
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  • 8
    Electronic Resource
    Electronic Resource
    The extended Graetz problem with prescribed wall flux (1980)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 26 (1980), S. 779-787 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An analytical solution is obtained to the extended Graetz problem with prescribed wall flux, based on a selfadjoint formalism resulting from a decomposition of the convective diffusion equation into a pair of first-order partial differential equations. The solution obtained is simple, computationally efficient and in striking contrast with incomplete numerical efforts in the past.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690260511
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  • 9
    Electronic Resource
    Electronic Resource
    Analysis of drop size distributions in lean liquid-liquid dispersions (1980)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 26 (1980), S. 991-1000 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Experimental measurements of transient drop size distributions in a stirred liquid-liquid dispersion (with low dispersed phase fraction) have been used concomitantly with population balance theory to recover the transition probability of droplet breakage, based on a similarity concept. The data remarkably uphold the proposed similarity hypothesis, and the estimated probability function displays the same qualitative trend as the model due to Narsimhan et al. (1979).
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690260614
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  • 10
    Electronic Resource
    Electronic Resource
    Breakage functions for droplets in agitated liquid-liquid dispersions (1984)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 30 (1984), S. 457-467 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Photographic measurements of transient drop-size distributions from stirred liquid-liquid systems of low dispersed phase fraction in a batch vessel confirm consistency with a similarity behavior from population balance established earlier by Narsimhan et al. (1980). Moreover, breakage functions are presented in generalized dimensionless form accounting for dependence on physical properties of the system and power input through stirring. This information is essential for predicting drop-size distributions in stirred liquid-liquid systems. Experimental measurements of steady-state drip-size distributions obtained from stirred, continuous flow systems with known inlet drop sizes compare very favorably with theoretical predictions based on population balance analysis using the breakage functions obtained from batch experiments.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690300315
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