ISSN:
1432-2013
Keywords:
ArterialP O2
;
Respiration
;
Blood Pressure
;
Chemoreflexes
;
Vagal Inactivation
;
Sinus Nerve Stimulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In anesthetized rabbits inhaling successively pure oxygen, air, and certain hypoxic O2/N2 mixtures, one cut carotid sinus nerve was stimulated under each of these conditions electrically with stimuli of constant intensity both before and after inactivation of the vagi by cold blocking and finally sectioning. In one group of these animals the contralateral sinus nurve was left intact, in the other it was cut. In the first group in which hypoxia produced a moderate hyperpnea with concomitant lowering of thePA CO2, the augmentation of ventilation by the nerve stimulation decreased markedly with thePa O2. In the latter group, where hypoxia caused no significant increase or even a slight diminution of ventilation, the respiratory effects of the nerve stimulating were not, or only inconsiderably influenced by the lowering of thePa O2, while the decrease of blood pressure induced normally by the stimulation was reversed into a distinct increase. After vagal inactivation the stimulatory effects on tidal volume were markedly greater, on respiratory frequency smaller, and on minute volume of ventilation (though only slightly and not always significantly) greater than before.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01023675
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