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  • 1
    Digitale Medien
    Digitale Medien
    Cell shape and cytoskeletal organization of the endothelial cells of the semilunar heart valves in the developing chick (1986)
    Springer
    Anatomy and embryology 174 (1986), S. 83-89 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Endothelial cells ; Cytoskeleton ; Semilunar valves ; Heart morphogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The composition and arrangement of the cytoskeletal elements of the endothelium of the semilunar valves have been studied in the embryonic chick heart during the stages 30 to 38. Microtubules, vimentin intermediate filaments and actin microfilaments were constant components of the valvular endothelial cells in the studied stages. Scanning electron microscopy after Triton-X-100 extraction revealed significant differences in the tridimensional arrangement of the cytoskeleton in the course of valve development. In the ventricular face of the cusps the cytoskeletal elements displayed a progressive longitudinal alignment, while in the arterial face of the cusps the cytoskeleton maintained the appearance of a network. Transmission electron microscopy revealed that these differences were especially prominent for vimentin intermediate filaments, although a similar tendency was also observed for microtubules. Microfilaments were scarce in the endothelial cells of both faces of the cusps, and the stress fibers typical of the endothelial cells of the adult valves were not observed in the embryonic material. The significance of these results in valve morphogenesis and histogensis and a possible linkage with differences in the local characteristics of the blood flow are discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00318339
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  • 2
    Digitale Medien
    Digitale Medien
    Immunofluorescent localization of tenascin during the morphogenesis of the outflow tract of the chick embryo heart (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 149-155 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Heart morphogenesis ; Truncus Arteriosus ; Extracellular matrix ; Tenascin ; Collagen type I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The cono-truncus constitutes a complex segment of the developing heart that gives rise to the outflow tract of the ventricles and root of the pulmonary and aortic arteries. Numerous studies have revealed that the extracellular matrix plays a relevant role in most morphogenetic processes modulating cell behaviour. By means of immunofluorescence, we studied the distribution and possible involvement of tenascin during morphogenesis of the conus and truncus in chick embryo hearts between days 4.5–10 of incubation. Tenascin is an extracellular matrix glycoprotein with a significant role in morphogenesis and cell and tissue differentiation. Our results reveal a specific distribution of tenascin in the areas of the cono-truncus undergoing significant structural changes during morphogenesis of this cardiac segment, appearing mainly in the mesenchymal layer subjacent to the myocardial layer, the cono-truncal ridges and the aorto-pulmonary septum. The distribution of tenascin was compared and contrasted with that of collagen type I, which constitutes a further component of the extracellular matrix common to most developing connective tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00198954
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  • 3
    Digitale Medien
    Digitale Medien
    Structural arrangement of the extracellular matrix network during myocardial development in the chick embryo heart (1991)
    Springer
    Anatomy and embryology 184 (1991), S. 451-460 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Extracellular matrix ; Ventricular myocardium ; Chick embryo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We analyzed the extracellular matrix and the connective tissue of the developing chick myocardium (“myocardial interstitium”). The importance of this myocardial element for heart function has been well documented both for the normal and pathologic adult hearts. However, little information is available on the organization of the embryonic myocardial interstitium and its modifications during development and increasing intracardiac pressure. In the present study we used light and scanning electron microscopic techniques, and lectin probes to study the interstitium of the ventricular myocardium of chick embryos from stage 29 (day 6 of development) until hatching. Our observations trace the progressive appearance and organization of the elements of the extracellular matrix, comprising the epimysium, perimysium and endomysium, which form a well-defined architectural network. Finally, we discuss the role of these elements of the extracellular matrix and their possible relation with the biomechanical properties of developing heart.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01236051
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  • 4
    Digitale Medien
    Digitale Medien
    Histogenesis of the semilunar valves: an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves (1990)
    Springer
    Cell & tissue research 259 (1990), S. 299-304 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Semilunar valves ; Extracellular matrix ; Tenascin ; Type-I collagen ; Heart morphogenesis ; Domestic fowl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The development of the semilunar valves takes place in association with septation of the outflow tract in the embryonic heart. Although numerous studies have focused on this process, the causal mechanisms of valvular development remain obscure. This paper reports an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves. Tenascin is a glycoprotein that is present on some embryonic extracellular matrices. It plays several significant roles in tissue differentiation, cell growth, and tissue interactions; it is also important for the formation of specific zones of connective tissue that fulfill mechanical functions. Our results show that tenascin is present during valvular morphogenesis and histogenesis, and that its distribution is associated with zones specialized in bearing mechanical loads.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00318452
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  • 5
    Digitale Medien
    Digitale Medien
    Effects of colchicine administration on the endothelial cells of the developing semilunar heart valves of the chick embryo (1987)
    Springer
    Cell & tissue research 250 (1987), S. 595-598 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Endothelial cells ; Heart morphogenesis ; Semilunar valves ; Colchicine ; Chick embryo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Recent ultrastructural studies have revealed that differences exist in endothelial cell shape and cytoskeletal architecture between the arterial and ventricular faces of developing semilunar valves. In the present work we analyzed the morphologic response of the valvular endothelial cells of chick embryos to colchicine by light microscopy, scanning electron microscopy and transmission electron microscopy. The results show that colchicine administration during the stages of valve morphogenesis causes a very conspicuous disruption of the endothelial layer of the arterial face of the valves. The cells appear rounded and show massive surface blebbing. These alterations were not present in the endothelial cells on the ventricular face of the valves at the same stages. On the basis of these results we suggest that a difference in the degree of cell differentiation exists between the endothelial cells of the arterial and ventricular faces of the cusps and that this difference may have morphogenetic significance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00218952
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