ISSN:
1615-2573
Keywords:
Chick embryo
;
Neutral crest cell
;
Cardiac anomaly
;
Cono-truncal anomaly
;
Hemodynamics
;
Vitelline artery blood pressure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Damage to premigratory cranial neural crest cells results in cardiovascular anomalies of so-called conotruncal anomaly. In one report, it was suggested that hemodynamic alteration would precede abnormal cardiovascular morphogenesis. We repeated this hemodynamic study in neural crest cell-excised chick embryos and found that there was no difference in heart rate and blood pressure between the treated embryos (n=11; 164±3 beats per min (BPM) and 0.75±0.03 mmHg, respectively) and control embryos (n=7; 160±6 BPM and 0.72±0.07 mmHg, respectively). The response of heart rate to acetylcholine was less (P〈0.05) in the treated embyos (−13% ±2%) than in the control (−20%±2%). Thus, the present data do not support the hypothesis that alterations in blood pressure and heart rate are causally related to abnormal cardiovascular morphogenesis. The developmental significance of subtle functional changes in neural crest-extirpated embryos in response to cholinergic challenge is unclear.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02058425
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