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Digitale Medien

Crohn's disease: the Melbourne experience (1992)

McLain, B. I. ; Davidson, P. M. ; Beasley, S. W. ; [weitere]

Springer

Pediatric surgery international 7 (1992), S. 165-170

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ISSN: 1437-9813

Schlagwort(e): Crohn's disease ; Childhood ; Bowel resection

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract During the years 1979–1988, 63 children (38 male: 25 female) were first diagnosed as having Crohn's disease on the basis of histological findings. Twenty-nine per cent were less than 10 years old at the onset of symptoms; 40% of these cases took more than 1 year to diagnose. Most patients (59%) presented with abdominal pain and diarrhoea, but 40% presented with: a non-specific illness (14%); upper gastro-intestinal tract symptoms (14%); growth failure (6%); systemic disease (5%), or peri-anal disease (1%). There were signs of abdominal tenderness, distension, or an abdominal mass in over 50% of cases. Peri-anal Crohn's disease was present in 41% and a height less than the 10th centile was recorded at diagnosis in 45%. Children were treated with a combination of prednisolone and sulphasalazine. In 16 cases a bowel resection was performed. Surgery was indicated for localised stricture formation causing obstruction and for persistence of severe disease poorly responsive to steroids, particularly in the prepubertal child with growth failure. The extent and distribution of disease influenced outcome. Twenty-four of 39 children followed for more than 3 years are either well-controlled or disease-free at present.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00175830

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Digitale Medien

Use of microgravity bioreactors for development of an in vitro rat salivary gland cell culture model (1993)

Lewis, Marian L. ; Moriarity, Debra M. ; Campbell, P. Samuel

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 51 (1993), S. 265-273

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ISSN: 0730-2312

Schlagwort(e): exocrine ; endocrine ; EGF ; signal transduction ; microgravity ; cell culture ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie , Medizin

Notizen: During development, salivary gland (SG) cells both secrete factors which modulate cellular behavior and express specific hormone receptors. Whether SG cell growth is modulated by an autocrine epidermal growth factor (EGF) receptor-mediated signal transduction pathway is not clearly understood. SG tissue is the synthesis site for functionally distinct products including growth factors, digestive enzymes, and homeostasis maintaining factors. Historically, SG cells have proven difficult to grow and may be only maintained as limited three-dimensional ductal-type structures in collagen gels or on reconstituted basement membrane gels. A novel approach to establishing primary rat SG cultures is use of microgravity bioreactors originally designed by NASA as low-shear culture systems for predicting cell growth and differentiation in the microgravity environment of space. These completely fluid-filled bioreactors, which are oriented horizontally and rotate, have proven advantageous for Earth-based culture of three-dimensional cell assemblies, tissue-like aggregates, and glandular structures. Use of microgravity bioreactors for establishing in vitro models to investigate steroid-mediated secretion of EGF by normal SG cells may also prove useful for the investigation of cancer and other salivary gland disorders. These microgravity bioreactors promise challenging opportunities for future applications in basic and applied cell research. © 1993 Wiley-Liss, Inc.

Zusätzliches Material: 3 Ill.