ISSN:
1432-198X
Keywords:
Henoch-Schönlein syndrome
;
IgA nephropathy
;
Common pathogenesis
;
Childhood
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract An 8-year-old Caucasian male presented with two episodes of gross hematuria but was otherwise asymptomatic. Serum IgA levels were markedly elevated and a renal biopsy showed mesangial proliferative glomerulonephritis with immunofluorescent and electron microscopy findings consistent with IgA nephropathy (IgAN). Two years later he developed abdominal pain, rectal bleeding, gross hematuria and a classic purpuric rash of Henoch-Schönlein syndrome (HSS). Serum IgA levels continued to be elevated and 3 years later in follow-up he is clinically well. These observations support the concept that HSS and IgAN are variants of the same process. The reverse situation has been reported in a 15-year-old female who developed HSS at 4 years of age and IgAN at age 15 years.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00853426
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