ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Diastereomer separation
;
Chiral derivatizing agent
;
Chiral oxazolidin-2-one
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary Chromatographic separation of racemic amines, carboxylic acids and alcohols can be achieved with excellent resolution as measured in terms of the chromatographic separation factor α by derivatization with a homochiral oxazolidin-2-one easily prepared in three steps fromendo-borneol. The resolved materials can be isolated in excellent yields by cleavage of the resultant diastereomers using conventional methods, which also allow recovery of the chiral resolving agent for re-use.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02290458
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