ISSN:
0749-1581
Keywords:
Chiral discrimination by NMR
;
Cyclodextrins
;
Telenzepine
;
Atropisomerism
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The influence of α-, β- and γ-cyclodextrin (CD) on the 1H NMR spectrum of the muscarinic antagonist telenzepine dihydrochloride in D2O is reported. Duplication of thienyl-H and thienyl-Me signals was observed in the presence of β- and γ-CD, with regard to the minor amido conformer in the former case and both major and minor amido conformers in the latter case. Use of CDs in chiral discrimination by NMR is now well known; the present results provide the first example of their application to an atropisomeric example.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260310421
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