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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 265-272 
    ISSN: 1432-1912
    Keywords: Vasodilator agents ; Vascular resistance ; Coronary circulation ; Collateral circulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method was applied in anesthetized dogs enabling the measurement of regional resistances up to and behind the start of collaterals and the collateral resistance. The studies show that peripheral coronary pressure, i.e. perfusion pressure of the collaterals, can change when the ratio of pre- and post-collateral resistance alters. Drugs can influence collateral blood flow not only by directly effecting the collaterals but also by altering collateral perfusion pressure. Glyceryl trinitrate given in minor doses improved collateral blood flow by directly dilating the collaterals and also by increasing collateral perfusion pressure. Higher doses did not improve collateral flow due to a decrease of collateral perfusion pressure. A stealphenomenon occurred in some cases. Adenosine and verapamil had no direct influence on the collateral resistance. Verapamil given in small doses increased perfusion pressure slightly but not enough to improve collateral blood flow. High doses of verapamil, like low doses of adenosine, had no significant influence on collateral perfusion pressure and collateral blood flow. Adenosine given in high dosage led to a diminution of collateral flow by decreasing collateral perfusion pressure, i.e. a steal-phenomenon.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 740-740 
    ISSN: 1435-2451
    Keywords: Gastroduodenal perforation ; Surgical therapy ; Outcome ; Magenperforation ; Chirurgische Terapie ; Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chirurgische Behandlung der Magenperforation besteht in erster Linie im sicheren Verschluß der Perforationsöffnung. Wünschenswert ist eine gleichzeitige Therapie der Ulcuskrankheit durch SPV bei jüngeren Patienten mit rezidivierenden Ulcera duodeni und mit einer weniger als 12 h alten Peritonitis. Berichtet wird über 95 Patienten. 63,8% hatten keine Ulcusanamnese oder eine über 12 h alte Peritonitis und wurden daher durch einfache übernähung versorgt. Die niedrige Rezidivquote (8,6% in 1–5 Jahren) rechtfertigt dieses Vorgehen. Die Letalität (22,1%) war vor allem beeinflußt vom Alter der Perforation, die bei 22% der Patienten über 24h zurücklag.
    Notes: Summary Surgical therapy for gastroduodenal perforation implies safe closure by simple suture. In some elective cases, it may also be advisable to combine this procedure with selective partial vagotomy to treat the underlying ulcer disease in younger patients with a long history of recurrent duodenal ulcer and with a perforation not older than 12 h. Our study included 95 patients. A great number of them (63.8%) had no history of ulcer disease or a perforation of more than 12 h standing and were treated by simple closure. The low incidence of recurrent ulcer (8.6% in 1–5 years) justifies our procedure. The mortality (22.1%) was mainly influenced by the time between perforation and operation. In 22 perforation was of more than 24 h standing.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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