ISSN:
1432-069X
Keywords:
Erythrodermic psoriasis
;
T-Cell subsets
;
Fe receptors
;
Monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In the present study the percentages of T cells and T-cell subsets, as defined by Fc receptors and monoclonal antibodies (OKT3, OKT4, OKT8, HLA-DR were determined in the peripheral blood of 12 patients with psoriasis, including six patients with erythroderma and 6 with active, but limited disease. The patients with erythroderma were studied before treatment and 4–8 weeks following. The mean percentages of E-rosette-forming cells and T-cell subsets reactive with the monoclonal antibodies OKT3, OKT4 and OKT8 were within normal limits, as were the percentages of Tμ-cells, irrespective of the extent or activity of the disease. The mean percentage of Tγ-cells was reduced in the patients with untreated erythrodermic psoriasis but not in the patients with limited disease. Comparison of the Tγ values in the erythroderma group before and after therapy showed a slight, but statistically significant increase (P〈0.03). These results indicate a direct relationship between the Tγ deficit and the extent of skin involvement, and argue against a primary suppressor T-cell defect in psoriasis vulgaris.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00406476
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