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  • 1
    Electronic Resource
    Electronic Resource
    The pathomorphological alterations of endocardial endothelium in experimental diabetes and diabetes associated with hyperlipidemia (1996)
    Springer
    Acta diabetologica 33 (1996), S. 41-47 
    Details
    ISSN: 1432-5233
    Keywords: Endothelium ; Endocardium ; Streptozotocin-induced diabetes ; Hyperlipidemia ; Atrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The structural alterations of endocardial endothelial cells of the heart right atrium and left ventricle were investigated in Golden Syrian hamsters subjected to streptozotocin-induced diabetes and to a combination of diabetes and diet-induced hyperlipidemia. Animals were examined at time intervals ranging from 2 weeks to 6 months. Anionic sites of the endothelial plasmalemma were visualized by in situ perfusion of cationized ferritin. The results indicated that: (a) both atrial and ventricular endocardial endothelium are affected in streptozotocin-induced diabetes: endothelium converts from continuous into a fenestrated type, (b) although the anionic charge of the plasmalemma decreased in advanced diabetes, the newly formed fenestrae highly bound cationized ferritin, (c) combined diabetes and hyperlipidemia induced more severe alterations of endocardial endothelium: new permeable endothelial structures were formed (transendothelial channels, open intercellular junctions, fused plasmalemmal vesicles), and the cells became particularly enriched in cytoskeleton (intermediate filaments and microtubules), (d) the thick subendocardial layer of connective tissue contained, in the combined experimental model, macrophage-derived foam cells indicative for the occurrence of alterations of atherosclerotic type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571939
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The pathomorphological alterations of endocardial endothelium in experimental diabetes and diabetes associated with hyperlipidemia (1996)
    Springer
    Acta diabetologica 33 (1996), S. 41-47 
    Details
    ISSN: 1432-5233
    Keywords: Key words  Endothelium ; Endocardium ; Streptozotocin-induced diabetes ; Hyperlipidemia ; Atrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   The structural alterations of endocardial endothelial cells of the heart right atrium and left ventricle were investigated in Golden Syrian hamsters subjected to streptozotocin-induced diabetes and to a combination of diabetes and diet-induced hyperlipidemia. Animals were examined at time intervals ranging from 2 weeks to 6 months. Anionic sites of the endothelial plasmalemma were visualized by in situ perfusion of cationized ferritin. The results indicated that: (a) both atrial and ventricular endocardial endothelium are affected in streptozotocin-induced diabetes: endothelium converts from continuous into a fenestrated type, (b) although the anionic charge of the plasmalemma decreased in advanced diabetes, the newly formed fenestrae highly bound cationized ferritin, (c) combined diabetes and hyperlipidemia induced more severe alterations of endocardial endothelium: new permeable endothelial structures were formed (transendothelial channels, open intercellular junctions, fused plasmalemmal vesicles), and the cells became particularly enriched in cytoskeleton (intermediate filaments and microtubules), (d) the thick subendocardial layer of connective tissue contained, in the combined experimental model, macrophage-derived foam cells indicative for the occurrence of alterations of atherosclerotic type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571939
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The 3′ untranslated regions of chloroplast genes inChlamydomonas reinhardtii do not serve as efficient transcriptional terminators (1996)
    Springer
    Molecular genetics and genomics 252 (1996), S. 676-683 
    Details
    ISSN: 1617-4623
    Keywords: Chlamydomonas ; Transcription termination ; Chloroplast transformation ; RNA processing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A general characteristic of the 3′ untranslated regions of plastid mRNAs is an inverted repeat sequence that can fold into a stem-loop structure. These stem-loops are superficially similar to structures involved in prokaryotic transcription termination, but were found instead to serve as RNA 3′ end processing signals in spinach chloroplasts, and in theatpB mRNA ofChlamydomonas reinhardtii chloroplasts. In order to carry out a broad study of the efficiency of the untranslated sequences at the 3′ ends of chloroplast genes inChlamydomonas to function as transcription terminators, we performed in vivo run-on transcription experiments usingChlamydomonas chloroplast transformants in which different 3′ ends were inserted into the chloroplast genome between apetD promoter and a reporter gene. The results showed that none of the 3′ ends that were tested, in either sense or antisense orientation, prevented readthrough transcription, and thus were not highly efficient transcription terminators. Therefore, we suggest that most or all of the 3′ ends of mature mRNAs inChlamydomonas chloroplasts are formed by 3′ end processing of longer precursors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02173973
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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