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  • 1
    ISSN: 1432-2072
    Keywords: Cannabis ; Chlorpromazine ; Amylobarbitone ; Rats' Social Behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of Δ 9-THC, chlorpromazine and amylobarbitone on the labor division achieved by rats were studied. While the first two drugs in the doses of, respectively, 5.0 and 3.0 mg/kg, induced an inversion in the social pattern, amylobarbitone was ineffective at doses of 10.0 and 20.0 mg/kg; labor division of rats trained under a CRF was more sensitive to the drugs effects than that of animals under a VI schedule of reinforcement. Results were discussed in terms of a drug induced deconditioning effect without loss of motivation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Amphetamine ; Chlorpromazine ; Butyrophenones ; Barbiturates ; Diazepam ; Open-field behavior ; Early treatments ; Maze learning ; Developmental psychopharmacology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male and female rats received during infancy either handling or injections of saline, phenobarbital, haloperidol, diazepam, chlorpromazine, and amphetamine. On reaching adulthood, the behavior of these animals was measured in an open-field arena and in a Lashley III maze. Saline injections per se affected the behavior of males but were unable to change that of females. The drugs provoked increased ambulation and/or decreased defecation of males in the open field, whereas with the females the opposite was observed, that is, a decreased ambulation and/or an increased defecation. Consequently, the early drug treatments abolished the sexual differences normally observed in ambulation and defecation of rats. Four of the 5 drugs tested deteriorated the maze performance of both male and female rats.
    Type of Medium: Electronic Resource
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