ISSN:
1432-1041
Keywords:
Chlorthalidone (Hygroton)
;
placental transfer
;
carbonic anhydrase binding
;
distribution in blood
;
elimination in milk
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary A gas chromatographic method has been used to determine chlorthalidone in amniotic fluid, maternal and foetal blood at delivery, and in maternal milk and blood three days after delivery, following the administration of chlorthalidone to nine pregnant women suffering from toxaemia of pregnancy. Placental transfer of chlorthalidone and elimination in maternal milk have been shown and the implications of these factors are discussed. An explanation has been proposed for our observations that foetal blood levels of the drug are about 15% of those in maternal blood.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609757
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