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  • 1
    Electronic Resource
    Electronic Resource
    Changes in liver blood flow after hepatectomy in conscious dogs (1996)
    Springer
    Surgery today 26 (1996), S. 688-693 
    Details
    ISSN: 1436-2813
    Keywords: liver blood flow ; hepatectomy ; concious dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hepatic circulation after hepatectomy was investigated in conscious dogs under fasting and feeding conditions. After a 40% hepatectomy, both the hepatic arterial and portal blood flow were measured simultaneously using ultrasonic transit time flowmeters. During fasting, the total hepatic blood flow (i.e., the sum of arterial and portal blood flow) changed in a biphasic pattern after hepatectomy. The first peak (517.9±42.7 ml/min; 130.1% of preoperative flow) was seen on the 1st postoperative day (POD) and the second peak (444.8±25.6 ml/min; 112.7% of preoperative flow) occurred on the 7th POD. The portal flow demonstrated the same biphasic changes as the total hepatic flow, although the hepatic arterial flow showed only the first peak. A heart rate analysis suggested that the first peak was probably due to hyperdynamic circulatory conditions, as has been previously reported. In addition, the existence of the second peak was established by the present study. The postprandial hepatic blood flow decreased during the first 2 weeks postoperatively, but exceeded the presurgical levels on PODs 21 and 28.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312085
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  • 2
    Electronic Resource
    Electronic Resource
    The role of polyamines in liver regeneration after hepatectomy with ischemic injury (1997)
    Springer
    Surgery today 27 (1997), S. 833-839 
    Details
    ISSN: 1436-2813
    Keywords: ischemia ; liver regeneration ; hepatectomy ; polyamine ; lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 175 rats were divided into: (1) a sham operation group, in which the liver was slightly mobilized after laparotomy; (2) a control group in which 68% of the liver was resected without the blockade of blood flow; (3) an ischemia + hepatectomy group, in which the vessels entering the right and caudate lobes were clamped for 30 min, and the nonischemic lobes were resected; (4) a DFMO + ischemia + hepatectomy group, in which the same procedure as for the ischemia + hepatectomy group was performed, but the animals received α-difluoromethylornithine (DFMO); (5) a DFMO + Put + ischemia + hepatectomy group, in which the animals underwent the same procedure, but were given putrescine (Put) in addition to DFMO. There were 6 to 7 rats in each of the five groups. The putrescine level and ornithine decarboxylase (ODC) activity were significantly higher in the ischemia + hepatectomy group than in the control group, but were markedly decreased in the DFMO + ischemia + hepatectomy group. However, the lipid peroxide level was significantly higher in the DFMO + ischemia + hepatectomy group than in the ischemia + hepatectomy group. The incorporation of [3H]thymidine in the DFMO + ischemia + hepatectomy group was significantly lower than that in the control group. The increase in the lipid peroxide level and the decrease in [3H]thymidine found in the DFMO + ischemia + hepatectomy group tended to be reversed by the administration of putrescine. These results suggest that putrescine suppressed the production of lipid peroxides and promoted DNA synthesis in regenerating the liver after ischemia-reperfusion injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02385274
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Value of percutaneous transhepatic cholangioscopy (PTCS) (1988)
    Springer
    Surgical endoscopy and other interventional techniques 2 (1988), S. 213-219 
    Details
    ISSN: 1432-2218
    Keywords: Percutaneous transhepatic cholangiography ; Percutaneous transhepatic biliary drainage ; Percutaneous transhepatic cholangioscopy ; Choledochoscopy ; Bile-duct carcinoma ; Endoscopic lithotripsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since July 1975, percutaneous transhepatic biliary drainage (PTBD) has been performed in 533 cases, and since April 1977 we have developed percutaneous transhepatic cholangioscopy (PTCS) as a diagnostic and therapeutic endoscopical tool in 198 cases of malignant disease and 195 benign cases. After dilating the sinus tract of PTBD using a 15-Fr catheter about 2 weeks after PTBD, PTCS was carried out through the sinus tract. PTCS has diagnostic advantages: the lesion can be accurately diagnosed histologically and the extent of cancer in the biliary tract can be assessed by taking biopsy specimens before the operation. PTCS has been applied for cholangioscopic lithotripsy in 145 cases of gallstone disease. In 44 cases, the Nd-YAG laser and/or electrohydraulic shock wave has been used to break up the stones. The PTCS morbidity was 6% and mortality was 0.3%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00705323
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Aggressive surgical treatment of hilar cholangiocarcinoma (1998)
    Springer
    Journal of hepato-biliary-pancreatic surgery 5 (1998), S. 52-61 
    Details
    ISSN: 1436-0691
    Keywords: Key words: aggressive surgery ; hepatectomy ; hilar cholangiocarcinoma bile duct cancer ; hepatobiliary surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Recent progress in surgical techniques for and the perioperative management of hilar cholangiocarcinoma has led to improved outcomes for aggressive liver and bile duct resections, which, however, still show considerable morbidity and mortality. In this article, the results of pioneers' attempts in hepatobiliary surgery for difficult hilar cholangiocarcinomas are reviewed. It is recommended that curative hepatobiliary resection should be performed for hilar cholangiocarcinoma, with careful preoperative management of patients complicated with several difficult conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00009951
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    Paper (German National Licenses)
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