ISSN:
1432-2072
Keywords:
Anxiety
;
Serotonin
;
Cortisol
;
Prolactin
;
Temperature
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The serotonin agonist m-chlorophenylpiperazine (m-CPP) had greater anxiogenic and other mood and cognitive effects when administered intravenously (0.1 mg/kg) rather than orally (0.5 mg/kg) to healthy subjects. Nonetheless, similar elevations in peak plasma cortisol and prolactin concentrations were obtained with the two dosage regimens, and temperature elevations were greater after oral m-CPP. Plateau phase plasma concentrations of m-CPP at the times of the maximum neuroendocrine responses to intravenous and oral m-CPP were similar. Since all rodent and nonhuman primate studies have used parenterally administered m-CPP, and previous clinical investigations using intravenous rather than oral m-CPP have yielded somewhat discrepant results, our normative data should be useful for comparing results, our normative data should be useful for comparing results across different human studies and across species.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00444705
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