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  • Chronic clenbuterol  (2)
  • Column liquid chromatography  (2)
  • Daucus carota L. ssp. sativus  (2)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1) (1986)
    Springer
    Journal of neural transmission 67 (1986), S. 215-224 
    Details
    ISSN: 1435-1463
    Keywords: Chronic clenbuterol ; methysergide ; 5-HT-1 binding sites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reserpine administration in mice causes, among other effects an akinesia which can be reversed by the serotonin agonist-antagonist methysergide. The effect of methysergide is potentiated by clenbuterol, a beta-adrenergic agonist, which itself causes hypomotility. Potentiation is weak after a single injection of clenbuterol, but becomes much stronger after repeated administration for 12 days. This treatment also causes a 50% increase in the number of high affinity 5-HT-1 binding sites in the brain. This increase would explain the increased potency of methysergide against reserpine-induced akinesia. These results show that: 1) a beta-adrenergic drug, clenbuterol modulates the serotoninergic system; 2) this modulation takes its importance after chronic treatment only; 3) this interrelation may be important in depressive illness since it is observed on a test used in the screening of antidepressant drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243349
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration (1987)
    Springer
    Psychopharmacology 91 (1987), S. 496-499 
    Details
    ISSN: 1432-2072
    Keywords: Motor activity ; Reserpine-induced hypothermia ; Chronic clenbuterol ; Tolerance ; Facilitation ; Central 5,7-DHT lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute clenbuterol, a beta-adrenergic stimulant, decreases motility and antagonizes reserpine-induced hypothermia in mice. After repeated treatment with clenbuterol, the hypomotility disappears (tolerance) but the antagonism of reserpine-induced hypothermia increases (facilitation). To investigate the function of serotonin in tolerance and facilitation, lesions of the serotonergic system were performed by intracerebroventricular administration of the neurotoxin 5,7 dihydroxytryptamine (5,7-DHT). After lesions of the serotonergic system, the tolerance to clenbuterol-induced hypomotility persists, but the facilitation of the antagonism by clenbuterol of reserpine-induced hypothermia disappears. Thus, the serotonergic nerve terminals must be intact for the latter but not the former response to occur. Since the reversal of reserpine-induced hypothermia in animals is predictive of antidepressant effects in man, it is suggested that the therapeutic action of clenbuterol in depressed patients may be mediated through the serotonergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00216017
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Linkage relationships among molecular markers and storage root traits of carrot (Daucus carota L. ssp. sativus) (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 58-64 
    Details
    ISSN: 1432-2242
    Keywords: Key words Genetic map ; RFLP ; AFLP ; RAPD ; SAMPL ; Daucus carota L. ssp. sativus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  A 109-point linkage map consisting of three phenotypic loci (P 1, Y 2, and Rs), six restriction fragment length polymorphisms (RFLPs), two random amplified polymorphic DNAs (RAPDs), 96 amplified fragment length polymorphisms (AFLPs), and two selective amplification of microsatellite polymorphic loci (SAMPL) was constructed for carrot (Daucus carota L. ssp. sativus; 2n=2x=18). The incidence of polymorphism was 36% for RFLP probes, 20% for RAPD primers, and 42% for AFLP primers. The overall incidence of disturbed segregation was 18%. Linkage relationships at a LOD score of 4.0 and θ=0.25 indicated 11 linkage groups. The total map length was 534.4 cM and the map was clearly unsaturated with markers spaced at 4.9 cM. AFLP P6B15 was 1.7 cM from P 1, AFLP P1B34 was 2.2 cM from Y 2, and AFLP P3B30XA was 8.1 cM from Rs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051208
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence for maternal inheritance of the chloroplast genome in cultivated carrot (Daucus carota L. ssp. sativus) (1999)
    Springer
    Theoretical and applied genetics 98 (1999), S. 669-672 
    Details
    ISSN: 1432-2242
    Keywords: Key words Chloroplast DNA ; Daucus carota L. ssp. sativus ; Maternal inheritance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The incidence and inheritance of a chloroplast DNA (cpDNA) mutation/marker, BP10U, was studied in crosses among cultivated carrots (Daucus carota ssp. sativus). BP10U is about 400 bp larger than the more common BP10L allele. The occurrence of BP10U among carrot inbreds was widespread. Individual plants exhibited only one form of BP10, and cpDNA inheritance was strictly maternal. BP10U only occurred in male-fertile plants. Some male-fertile inbreds and all cytoplasmically male-sterile (petaloid) carrots had the BP10L allele. Alloplasmic cpDNA variation has been reported previously in Daucus, but this is the first report of variation and inheritance of cpDNA within cultivated carrot.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051119
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Air-sampling of aldehydes—Application to chromatographic determination of formaldehyde and acetaldehyde (1984)
    Springer
    Chromatographia 18 (1984), S. 137-144 
    Details
    ISSN: 1612-1112
    Keywords: Aldehydes and ketones ; 2,4-dinitrophenylhydrazine-coated silica gel ; Gas chromatography ; Column liquid chromatography ; Pollution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary After a brief review of several methods described in the literature this paper discusses air-sampling on 2,4-dinitrophenylhydrazine-coated silica gel and identification requirements for aldehydes and ketones most commonly found in industrial pollution. Quantitative analysis of formaldehyde and acetaldehyde either by GC or by HPLC techniques is established using a dynamic system producing test atmospheres and compared with the usual colorimetric determinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02258770
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A solvent-free sampling method for airborne toluene diisocyanate (1987)
    Springer
    Chromatographia 23 (1987), S. 507-511 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Toluene Diisocyanate in air ; Collector for air sampling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A useful method of sampling and measurement of toluene diisocyanate concentration in atmosphere is described. The sampler consists of glass-fibre filters impregnated with the reagent 1-(2-methoxyphenyl)piperazine1 so that the 2,4 and 2,6 isomers of TDI react to form urea derivatives which are analysed by high performance liquid chromatography in isocratic mode on cyan-amino and C18 bonded phases. A dynamic system was used to generate standard atmospheres of TDI and to validate the sampling method within the humidity range of 0% to 75%. A coated filter, a bubbling solution and an impregnated silica gel were compared as samplers requiring the piperazine reagent in performance experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02309420
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    Paper (German National Licenses)
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