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  • 1
    Electronic Resource
    Electronic Resource
    24 Jahre Überlebenszeit bei chronisch-myeloischer Leukämie (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 673-676 
    Details
    ISSN: 1432-1440
    Keywords: Chronic myeloid leukemia ; Long survival ; Miliary tuberculosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 55-year old woman was diagnosed as having chronic myeloid leukemia in 1961. After 9 years with stable white blood cells, progression of the disease was noted (white cells up to 180×109/l; splenomegaly to the umbilicus). Busulfan was given over 4 weeks resulting in a remission of 13 years duration. Progression was observed again in 1983, 22 years after the initial diagnosis of chronic myeloid leukemia. Therapy with hydroxyurea resulted in another remission of shorter duration. Two chromosome studies showed the Philadelphia chromosome in 100% of metaphases without additional aberrations. In 1985 blast crisis developed. The cause of death as determined at autopsy was an undiagnosed miliary tuberculosis. The presented case is of special interest since (1) it is a report of the longest surviving patient with chronic myeloid leukemia, and (2) in contrast to other cases with long survival, this patient did not show chromosomal mosaicism or any additional chromosomal aberrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875503
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interferon in chronic myeloid leukemia (1993)
    Springer
    Annals of hematology 67 (1993), S. 101-106 
    Details
    ISSN: 1432-0584
    Keywords: Chronic myeloid leukemia ; Interferon ; Hydroxyurea ; Busulfan ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The therapeutic efficacy of interferon-alpha (IFN-α) in the treatment of chronic myeloid leukemia is currently being tested in a number of institutional, interinstitutional, and international trials. There is no doubt that responses are achieved in many patients, and in a small subset complete eradication of clonogenic cells may be possible. However, it has not yet been shown that overall survival of patients treated with IFN-α is better than that of those treated with conventional cytoreductive drugs. There are still controversial opinions on problems such as dosages and duration of treatment, combination with cytostatic agents, definition of responses, and relevance of cytogenic and molecular data. An international workshop discussed the data on interferon therapy and attempted to define the role of interferon today in the management of chronic myeloid leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01788134
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relapsing acute febrile neutrophilic dermatosis and essential thrombocythemia (1984)
    Springer
    Annals of hematology 48 (1984), S. 297-305 
    Details
    ISSN: 1432-0584
    Keywords: Acute febrile neutrophilic dermatosis ; Essential thrombocythemia ; Sweet's syndrome ; Paraneoplastic disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Relapsing acute febrile neutrophilic dermatosis (AFND) is reported in a patient with essential thrombocythemia representing the first case of this kind described in the literature. The patient presented with fever, malaise, neutrophilic leukocytosis, dysproteinemia, and coalescing bluish-red painful plaques and papules at palms, forehead, lid, forearm, and thigh. There was a dramatic response to steroids, or indomethacin, with no scarring. AFND was preceded by sore throat and an upper respiratory infection and was accompanied by conjunctivitis and arthritis of knees and ankle-joint. The association of AFND with essential thrombocythemia and with other neoplastic disorders is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320401
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Thrombozytenfunktion bei essentieller Thrombozythämie und reaktiver Thrombozytose (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 199-207 
    Details
    ISSN: 1432-1440
    Keywords: Essential thrombocythemia ; Platelet aggregation studies in essential thrombocythemia ; Epinephrine-induced platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Blood of 16 patients with essential thrombocythemia (ET), 9 patients with reactive thrombocytosis (RT) and 13 healthy persons was used for platelet aggregation studies. When the aggregation was induced with adenosine diphosphate (0.01 µM), collagen (0.1 µg/ml) or platelet activating factor (PAF 0.5 µM) the plasma of the patients with ET showed significantly decreased aggregation (35%–44% of the value for the control groups). Independent of inhibitors of platelet aggregation, thrombin (0.05 U/ml) caused similar aggregation in healthy controls and patients with ET; patients with RT showed an increased aggregation. Adrenalin-induced aggregation discriminated best between patients with ET and controls. Adrenalin in concentrations ranging from 0.01 µg/ml to 100 µg/ml caused comparable dose-related amounts of aggregation in healthy controls and patients with RT. Over the whole concentration range, patients with ET showed significantly decreased aggregation (28%–34% of the value for the control groups). This difference proved to be independent of the influence of inhibitors of platelet aggregation. Though concentrations of alpha1-acid glycoprotein never reached inhibitory levels in the plasma of patients with ET (n=12) they were significantly higher compared with those in normal plasma (n=12). Fibrinogen concentrations in plasma of ET-patients (n=12) were in the normal range. Cellular adenosine 3′–5′-cyclic monophosphate concentrations in ET (n=10) are comparable with normal values (n=5). The significance of the results for diagnosis and better pathophysiological understanding of ET is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728197
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    Paper (German National Licenses)
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