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  • 1
    Electronic Resource
    Electronic Resource
    Changes of nucleolar organizer regions in granulopoietic precursors during the course of chronic myeloid leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 275-279 
    Details
    ISSN: 1432-0584
    Keywords: Nucleolar organizer regions ; Chronic myeloid leukemia ; Cytokinetics ; Myeloproliferative disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to analyze the nucleolar organizer region (AgNOR) pattern of granulopoietic precursors in chronic myeloid leukemia (CML) at diagnosis and during the course of the disease. Clusters of AgNORs and isolated dots were counted separately in 24 cases of CML at diagnosis, in 19 cases during the relapse of the chronic phase after treatment, and in 16 cases of blast crisis. For comparison, 20 cases of normal bone marrow were studied. Each cell type had its own characteristic AgNOR pattern, as has been described for normal bone marrow. There was no significant difference in the number of AgNORs between cells in the peripheral blood and bone marrow. Compared with normal granulopoiesis, myeloblasts in CML at diagnosis had lower numbers of clusters, which decreased further during relapse of chronic phase and in blast crisis. Promyelocytes and myelocytes showed significantly fewer dots. The number of AgNOR clusters correlates inversely with the duration of the cell cycle. Therefore, these findings are consistent with the progressive loss in proliferative activity of immature precursors described during the course of CML. As the number of dots indicates cellular maturation, their lower number in promyelocytes and myelocytes in CML favors the concept of a discordant maturation process described in this desease. The separate counting of clusters and dots provides a useful, simple, and cheap method of describing cytokinetic changes during the course of this myeloproliferative
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01697979
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Changes of nucleolar organizer regions in granulopoietic precursors during the course of chronic myeloid leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 275-279 
    Details
    ISSN: 1432-0584
    Keywords: Key words Nucleolar organizer regions ; Chronic myeloid leukemia ; Cytokinetics ; Myeloproliferative disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of the present study was to analyze the nucleolar organizer region (AgNOR) pattern of granulopoietic precursors in chronic myeloid leukemia (CML) at diagnosis and during the course of the disease. Clusters of AgNORs and isolated dots were counted separately in 24 cases of CML at diagnosis, in 19 cases during the relapse of the chronic phase after treatment, and in 16 cases of blast crisis. For comparison, 20 cases of normal bone marrow were studied. Each cell type had its own characteristic AgNOR pattern, as has been described for normal bone marrow. There was no significant difference in the number of AgNORs between cells in the peripheral blood and bone marrow. Compared with normal granulopoiesis, myeloblasts in CML at diagnosis had lower numbers of clusters, which decreased further during relapse of chronic phase and in blast crisis. Promyelocytes and myelocytes showed significantly fewer dots. The number of AgNOR clusters correlates inversely with the duration of the cell cycle. Therefore, these findings are consistent with the progressive loss in proliferative activity of immature precursors described during the course of CML. As the number of dots indicates cellular maturation, their lower number in promyelocytes and myelocytes in CML favors the concept of a discordant maturation process described in this desease. The separate counting of clusters and dots provides a useful, simple, and cheap method of describing cytokinetic changes during the course of this myeloproliferative disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01697979
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    277. Gibt es spezifische und dosisabhängige histologische Veränderungen in Nierentransplantaten unter Cyclosporin-Therapie? (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 897-897 
    Details
    ISSN: 1435-2451
    Keywords: Renal transplantation ; Cyclosporin A ; Histology ; Nierentransplantation ; Cyclosporin ; Histologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer prospektiv randomisierten Studie wurden 71 Leichennierenempfänger mit einer hohen, 73 mit einer niedrigen Cyclosporin-Dosis behandelt. Der mittlere Vollblutspiegel betrug 250 bzw. 500 ng/ml. Wegen unzureichender Funktion durchgeführte Biopsien zeigten bei ver gleichbarer Abstossungsrate in der niedrigen Gruppe in 46%, in der hohen jedoch in 70% eine Fibrose sowie hier zusätzlich Tubulusläsionen. Die 2-Jahres-Funktionsrate war in der niedrigen Gruppe geringfügig, aber nicht signifikant besser (82/77%). Aufgrund der dosisabhängigen histologischen Veränderungen sollte Cyclosporin demnach niedrig dosiert werden.
    Notes: Summary In a prospective random trial, 71 recipients of cadaver kidneys were treated with a high dose of cyclosporin A and 73 recipients with a low dose. The mean whole blood levels were 250 and 500 ng/ml, respectively. Biopsies performed for insufficient function showed fibrosis in 46% of the low-dose group compared to 70% in the high-dose group. Moreover, in the latter, tubular lesions were found. The rejection rates were similar in both groups. The 2-year function rate in the low-dose group was slightly but not significantly better (82/77%). Due to the dose-dependent histological findings, cyclosporin A should be given in low dosages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298061
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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