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  • Chronic sinusitis  (1)
  • Middle ear effusion  (1)
  • Protease inhibitors  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 245 (1988), S. 42-46 
    ISSN: 1434-4726
    Keywords: Antigen-induced otitis media ; Human serum albumin ; Middle ear effusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between antigen levels in middle ear effusions (MEE) and the degree of middle ear inflammation was studied in an antigen-induced otitis media model, using chinchillas sensitized with human serum albumin (HSA). The degree of middle ear inflammation was evaluated by both tympanometric analysis, and cytological and biochemical analyses of the MEE. Middle ear inflammation develops after HSA challenge with a remarkable decrease in HSA levels in the MEE. This inflammation persists even when HSA levels are no longer detectable in the MEE. These findings show that local challenges with an antigen induce a certain degree of middle ear inflammation, which continues even after complete elimination of the antigen from the middle ear through an immunological defense mechanism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 123-125 
    ISSN: 1434-4726
    Keywords: Chronic sinusitis ; Nasal polyps ; Interleukin-1α ; Interleukin-1β ; Monocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have measured interleukin-1α (IL-1α) and β levels in nasal polyps (NP) from patients with chronic sinusitis (CS) in order to determine their significance in the pathogenesis of NP. NP in ten cases (five male and five female; age range, 17–63 years) were removed to separate mononuclear (M) and polymorphonuclear (PMN) fractions through Ficoll-Paque separation media. ELISA measurements of the M fraction showed that the mean value of IL-1β was 17.8 pg/mI per gram, which was significantly higher than that of IL-1α (7.04 pg/ml per gram, P〈0.01, Wilcoxon test). In the PMN fraction, the mean value of IL-1α was 8.79 pg/ml per gram and that of IL-β was 7.85 pg/ml per gram, which was not significantly different. Mononuclear leukocytes, particularly activated monocytes, seem to be a major source of IL-1 in the NP taken from patients with CS.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 218-221 
    ISSN: 1434-4726
    Keywords: Otitis media with effusion ; Protease inhibitors ; Vascular permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vascular permeability (VP) of the middle ear mucosa (MEM) in chronic otitis media with effusion (OME) was estimated in both pediatric and adult patients by calculating the middle ear effusion (MEE) to serum concentration ratios of albumin and of four protease inhibitors: α1-antitrypsin (α1-AT), α1-antichymotrypsin (α1-X), inter-α-trypsin inhibitor (I-α-I) and α2-macroglobulin (α2-M). The levels of albumin and α1-AT in MEE were higher while those of I-α-I and α2-M were lower than their serum levels in both adult serous and pediatric mucoid groups. There was a negative correlation between molecular weight and the mean value of the ratio (MEE/serum) of the four inhibitors in both serous (r=−0.989) and mucoid (r=−0.924) groups. Vascular permeability of the MEM seems to be variable in both serous and mucoid groups during middle ear inflammation. Selective leakage of proteins by molecular weight appears to occur in MEM. Our findings further indicate that a high level of the high-molecular-weight inhibitor α2-M in MEE may be a significant index reflecting the remarkably enhanced VP of the MEM.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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