ISSN:
1432-1912
Keywords:
Angiotensin-converting enzyme inhibitors
;
Captopril
;
Cilazapril
;
Thromboxane B2 (TxB2)
;
6-keto-prostaglandin F1α (6-keto-PGF1α)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have studied in 12 healthy volunteers the effects of two angiotensin-converting enzyme (ACE) inhibitors, captopril and cilazapril, on vascular and platelet prostaglandin metabolism, in a double-blind, placebo-controlled, randomized cross-over study. Formation of 6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2 (TxB2) was measured locally at the site of a microvascular injury. Similar amounts of TxB2 and 6-keto-PGF1α were generated following administration of either ACE inhibitor as compared to placebo. It is concluded that neither captopril nor cilazapril significantly influence vascular and platelet prostaglandin metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00171089
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