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  • Oncogene activation  (2)
  • Cisplatin, cis-diamminedichloroplatinum (II)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Binding of cisplatin to specific sequences of human DNA in vitro
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 202 (1988), S. 133-138 
    Details
    ISSN: 0027-5107
    Keywords: Cisplatin, cis-diamminedichloroplatinum (II) ; G, deoxyguanosine monophosphate residue in DNA ; HPRT, hypoxanthine-guanine phosphoribosyltransferase ; dNTP,, deoxyribonucleoside triphosphate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0027-5107(88)90174-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    DNA adducts in experimental cancer research (1986)
    Springer
    Journal of cancer research and clinical oncology 112 (1986), S. 181-188 
    Details
    ISSN: 1432-1335
    Keywords: Initiation ; Oncogene activation ; Styrene oxide ; Cisplatin ; Carcinogenic potency ; TD50
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined point mutation. The properties of two DNA binding agents, styrene oxide and cisplatin are discussed. Styrene oxide is a versatile electrophile causing numerous adducts; cisplatin has a high specificity towards guanine-N-7 and cross-link formation. Finally, the relation of specific adducts to carcinogenic potency as defined by TD50 values is investigated. For small alkyl groups, O-alkylation of bases correlates with potency but among others, particularly the bulky carcinogens, 7-alkylguanines appear as correlates of potency. Most such potent agents forming 7-alkylguanines induce depurination and imidazole ring-opening.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395910
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Protein binding, sister chromatid exchange and expression of oncogene proteins in patients treated with cisplatinum (cisDDP)-based chemotherapy (1990)
    Springer
    Archives of toxicology 64 (1990), S. 401-406 
    Details
    ISSN: 1432-0738
    Keywords: Carcinogen-protein binding ; Sister chromatid exchange ; Oncogene activation ; Cisplatinum ; Biologic markers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this pilot was to evaluate the feasibility of incorporating several complementary biologic markers into a molecular epidemiologic study of chemotherapy patients. Thirty-two cancer patients being treated withcis-DDP-based chemotherapy for the first time were enrolled in the study and donated a baseline sample and at least one post-treatment sample of blood. Sister Chromatid Exchange (SCEs) and plasma protein and hemoglobin binding bycisDDP were significantly increased in samples drawn at various timepoints following treatment. The pattern of nine different oncogene protein products (including those ofras, fes, andmyc) remained unchanged in sera of six patients followed over the course of their treatment. However, the levels ofras P21 product were significantly elevated above normal, control levels in all six cancer patients — both prior to and throughout the course of chemotherapy. These results suggest the usefulness of utilizing a battery of markers to evaluate biologic response to cisplatinum-based chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973463
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    Paper (German National Licenses)
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