ISSN:
1590-3478
Keywords:
Key words Limb-girdle muscular dystrophy
;
CT scan
;
Clinical scale
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Knowledge of selective muscle-involvement is useful to the clinician. Therefore we investigated in sarcoglycanopathy and dysferlinopathy: (i) the correlation between clinical scale, MRC scale and CT findings and (ii) the muscles involved. Patients with a definite diagnosis of dysferlinopathy and sacroglycanopathy were tested for their clinical functions and muscle strength and assigned a functional grade. Nineteen muscles were evaluated by CT. In dysferlinopathy, distal lower-limb muscles are involved, while in sarcoglycanopathy proximal muscles are more affected. In both groups, muscles with MRC 〈3 often had severe abnormalities on CT imaging, while muscles with MRC 〉4 could be either normal or abnormal. Dysferlinopathy and sarcoglycanopathy have different and selective muscle involvement. This may affect certain types of functional activity. There is a possible relationship between CT findings and MRC grade in muscles with a low (〈3) MRC grade. Abnormality on CT scan may precede the clinical symptoms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s100720070013
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