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  • 1
    Electronic Resource
    Electronic Resource
    A prospective study of the effect of 12 months treatment on serum lipids and apolipoproteins A-I and B in type 2 (non-insulin-dependent) diabetes (1982)
    Springer
    Diabetologia 23 (1982), S. 507-510 
    Details
    ISSN: 1432-0428
    Keywords: Type 2 diabetes ; prospective study ; diet ; metformin ; glibenclamide ; HDL-cholesterol ; total cholesterol ; triglyceride ; apolipoproteins A-I and B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum high density lipoprotein cholesterol, total cholesterol, triglyceride and apolipoproteins A-I and B were studied at diagnosis and after 12 months conventional treatment in a group of Type 2 (non-insulin-dependent) diabetic patients. No significant deleterious effect on serum lipids and apolipoproteins was seen in any of the subgroups during the treatment period, although in the overall group there was a significant increase in serum total cholesterol in females. Serum high density lipoprotein cholesterol increased significantly in obese males treated with calorie restriction alone. There was a significant increase in serum apolipoprotein A-I in obese females treated with calorie restriction and metformin and in non-obese females treated with carbohydrate restriction and glibenclamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254300
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes (1981)
    Springer
    Diabetologia 20 (1981), S. 535-539 
    Details
    ISSN: 1432-0428
    Keywords: HDL-cholesterol ; apolipoprotein A-I ; non-insulin dependent diabetes ; hypertriglyceridaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary High-density lipoprotein (HDL) cholesterol levels were decreased in patients with non-insulin dependent diabetes at diagnosis when matched with a control population for sex, age, obesity, alcohol consumption and cigarette smoking. There was no association between serum HDL-cholesterol concentration and the percentage of glycosylated haemoglobin A1 (HbA1). Serum HDL-cholesterol levels were lower in diabetics over the whole range of serum triglyceride levels, and particularly in hypertriglyceridaemic diabetics. Serum apolipoprotein A-I levels were not decreased in diabetics with normal serum triglyceride levels, so that the ratio of HDL cholesterol to apolipoprotein A-I was significantly decreased in diabetics (p〈0.005). Decreased HDL cholesterol levels in non-insulin dependent diabetes could be relevant to the subsequent development of atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252761
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Retarded acquisition and reduced expression of conditioned locomotor activity in adult rats following repeated early maternal separation: effects of prefeeding,d-amphetamine, dopamine antagonists and clonidine (1996)
    Springer
    Psychopharmacology 126 (1996), S. 75-84 
    Details
    ISSN: 1432-2072
    Keywords: Maternal separation ; Conditioned incentive stimuli ; Conditioned locomotor activity ; Mesolimbic dopamine ; Amphetamine ; Sulpiride ; SCH 23390 ; Clonidine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adult hooded rats exposed to a repeated maternal separation procedure during the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration. We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the response-enhancing effects of systemicd-amphetamine (0.5; 1.0 mg/kg) and to the response-attenuating effects of the selective dopamine D2 antagonist sulpiride (8; 20 mg/kg), the selective dopamine D1 antagonist SCH 23390 (0.01; 0.022 mg/kg) and the mixed α1/α2 adrenoceptor agonist clonidine (5; 15 μg/kg) in a dose dependent manner. Animals from the early separation groups showed a reduced enhancement of activity in response to 0.5 mg/kgd-amphetamine and a greater attenuation of activity in response to 8 mg/kg sulpiride and 5 μg/kg clonidine. Female separated rats also exhibited an attenuated locomotor response to the unconditioned stimulant effects of 0.5 mg/kg systemicd-amphetamine. The experiments confirm that early maternal separation attenuates the response to conditioned appetitive cues in adult rats and implicate altered dopaminergic and noradrenergic function in the changes. It is possible that early maternal separation in the rat may offer a useful preparation for investigation of the neural substrates mediating affective development and affective psychopathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246414
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    Paper (German National Licenses)
    Fulltext
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