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  • Clozapine  (1)
  • Column liquid chromatography  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A prospective study of clozapine in treatment-resistant schizophrenic patients (1989)
    Springer
    Psychopharmacology 99 (1989), S. S68 
    Details
    ISSN: 1432-2072
    Keywords: Clozapine ; Treatment-resistant schizophrenia ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preliminary results of a non-blinded prospective study of the effect of clozapine on symptomatology and social function in 51 treatment-resistant schizophrenic patients are reported. The mean duration of treatment at the time of this report was 10.3±8.1 months, median 7.6 months. Overall, 3/51 patients (60.8%) showed at least a 20% decrease in total BPRS, a criterion of improvement in the study of Kane et al. (1988). Four of 51 (7.8%) had at least a 50% decrease in total BPRS. Improvements in both positive and negative symptoms were noted. Marked improvements in social function were noted within the first 6 months of treatment. Improvement was first noted at all time points, with only 45.2% of improvers being identified after 6 weeks of treatment. These results suggest a 6–12-month trial may be desirable before deciding to discontinue clozapine because of insufficient response. Higher total Brief Psychiatric Rating Scale (BPRS) score and higher ratings on the Paranoid Disturbance subscales of the BPRS were factors which discriminated clozapine responders from non-responders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442563
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Simultaneous determination of Ibuproxam and Ibuprofen in human plasma by HPLC with column switching (1993)
    Springer
    Chromatographia 37 (1993), S. 618-622 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ibuproxam and Ibuprofen in plasma ; Column switching
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A new high-performance liquid chromatographic method with column switching has been developed for the simultaneous determination of Ibuproxam and its metabolite Ibuprofen in plasma. The plasma samples were injected onto a LiChrosorb RP-8 precolumn after dilution with an internal standard solution in phosphoric acid. Polar plasma components were eluted with 0.05 M phosphoric acid. After valve switching, the concentrated drugs were eluted in the back-flush mode and separated on an Inertsil ODS-2-column with acetonitrile-methanolphosphate buffer as mobile phase. The method showed excellent precision, accuracy and speed with detection limit of 0.1 μg ml−1. Total analysis time per sample was less than 30 min and the coefficients of variation for intra and inter-assay were less than 3.5%. This method has been successfully applied to plasma samples from human volunteers after oral administration of Ibuproxam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274112
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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