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  • 1
    Digitale Medien
    Digitale Medien
    Nutritional vitamin B12 deficiency: Two cases detected by routine newborn urinary screening (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 218-220 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Vitamin B12 ; Methylmalonic aciduria ; Newborn screening ; Cobalamin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We describe two asymptomatic newborns with nutritional vitamin B12 deficiency in whom increased urinary methylmalonic acid was detected by routine neonatal screening at 3 weeks of age. Both infants were exclusively breast-fed. One mother suffered from pernicious anaemia, and the other was a strict vegetarian. Both mothers had no clinical or haematological abnormality, aside from a borderline mean corpuscular volume for the vegetarian mother. This report illustrates the early appearance of functional vitamin B12 deficiency in breastfed infants of vitamin B12-depleted mothers. It also demonstrates that urinary methylmalonic acid measurement is a sensitive indicator of tissue vitamin B12 deficiency.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01954389
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Analysis of Arabidopsis thaliana transgenic plants transformed with CER2 and CER3 genes in sense and antisense orientations (1998)
    Springer
    Theoretical and applied genetics 97 (1998), S. 801-809 
    Details
    ISSN: 1432-2242
    Schlagwort(e): Key words Arabidopsis thaliana ; Epicuticular wax biosynthesis ; Eceriferum mutants ; Glossy mutants ; Transgenic plants
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract  A number of genes involved in the biosynthesis of the epicuticular wax (EW) of Arabidopsis thaliana have recently been isolated through genetic approaches. In view of the evidence in favor of the importance of EW compounds in the adaptation of higher plants to a number of physiological and ecological stresses, we have used clones of some of these genes to genetically engineer constructs with which to manipulate EW biosynthesis in transgenic A. thaliana plants. All our constructs were placed under the control of the near constitutive CaMV 35S promoter. We were able to complement mutant plants with the construction in the sense orientation as well as induce phenocopies of the eceriferum phenotype by transforming wild-type plants with both the sense and antisense constructs. We observed reduced fertility in the wild-type plants transformed with the 35SCER3sense or 35SCER3antisense constructs but not in those transformed with the 35SCER2sense or 35SCER2antisense constructs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001220050959
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