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  • 1
    ISSN: 1530-0358
    Keywords: Paradoxical puborectalis contraction ; Nonrelaxing puborectalis syndrome ; Anismus ; Constipation ; Defecography ; Electromyography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective study was undertaken to assess the correlation between electromyography (EMG) and cinedefecography (CD) for the diagnosis of nonrelaxing puborectalis syndrome (NRPR). Clinical criteria for NRPR included straining, incomplete evacuation, tenesmus, and the need for enemas, suppositories, or digitation. EMG criteria included failure to achieve a significant decrease in electrical activity of the puborectalis (PR) during attempted evacuation. CD criteria included either paradoxical contraction or failure of relaxation of the PR along with incomplete evacuation. In addition, other etiologies for incomplete evacuation, such as rectoanal intussusception or nonemptying rectocele, were excluded by proctoscopy and defecography in all cases. One hundred twelve patients with constipation, 81 females and 31 males, with a mean age of 59 (range, 12–83) years were studied by routine office evaluation, CD, and EMG. Forty-two patients (37 percent) had evidence of NRPR on CD (rectal emptying: none, 24; incomplete, 18). Twenty-eight of these patients (67 percent) also had evidence of NRPR on EMG. EMG findings of NRPR were present in 12 of 70 patients (17 percent) with normal rectal emptying. Conversely, 14 of 72 patients (19 percent) with normal PR relaxation on EMG had an NRPR pattern on CD. The sensitivity and specificity for the EMG diagnosis of NRPR were 67 percent and 83 percent, and the positive and negative predictive values were 70 percent and 80 percent, respectively. Conversely, if EMG is considered as the ideal test for the diagnosis of NRPR, CD had a sensitivity of 70 percent, a specificity of 80 percent, and positive and negative predictive values of 66 percent and 82 percent, respectively. In summary, sensitivity, specificity, and predictive values of EMG and CD are suboptimal. Therefore, a combination of these two tests is suggested for the diagnosis of NRPR.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1530-0358
    Keywords: Biofeedback ; Constipation ; Anismus ; Pelvic outlet obstruction ; Paradoxical puborectalis contraction ; Spastic pelvic floor syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eighteen patients with chronic constipation were diagnosed as having paradoxical puborectalis contraction (PPC) as the cause for their constipation. The diagnosis of PPC was made after office evaluation, colonic transit study, manometry, cinedefecography, and electromyography (EMG). These 18 patients had a mean duration of symptoms of 26.9 years; none of these patients had unassisted bowel movements. Fourteen patients had a mean of 4.6 laxative-induced bowel evacuations per week, and 11 patients had a mean of 4.4 enema-induced bowel evacuations per week. Patients underwent a mean of 8.9 one-hour EMG-based biofeedback sessions. At a mean follow-up of 9.1 (range, 0.5–12) months, these 18 patients had a mean of 7.3 unassisted bowel actions per week ( P 〈0.0001). In addition, persistent laxative use was reported by only two patients, and, in both cases, this was once a week or less ( P 〈0.001). Similarly, enema use was reported by only three patients, one once weekly and the other two thrice weekly ( P 〈0.002). No biofeedback-related complications were identified. EMG-based biofeedback is a valuable technique associated with an 89 percent success rate in the treatment of PPC.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1530-0358
    Keywords: Defecography ; Proctography ; Balloon sphincterography ; Anorectal angle ; Constipation ; Fecal incontinence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective study was undertaken to compare two different methods of measuring the anorectal angle (ABA), balloon proctography (BP) and cinedefecography (CD), as well as to evaluate the reproducibility of this measurement using each technique. One hundred four consecutive patients (75 women and 29 men) with constipation (63 patients), fecal incontinence (25 patients), or rectal pain (16 patients) underwent both BP and CD. The ARA was measured by taking lateral radiographs of the pelvis during rest (R), squeeze (S), and push (P). The same interpretation process was performed 2 to 12 months later by the same observer, blinded as to diagnosis and initial measurements. There were highly significant differences in each measurement category, R ( P 〈 0.0001), S ( P 〈 0.0001), and P ( P 〈 0.0004 between BP and CD. However, the correlation between the first and second measurements was excellent ( P 〈 0.0001). BP was consistently more difficult to interpret because of balloon configuration. Although BP and CD have poor correlation with each other, each examination can be reliably interpreted. CD appears to be a superior examination because of the added ability to delineate rectoceles, intussusceptions, and other structural defects.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 34 (1991), S. 606-612 
    ISSN: 1530-0358
    Keywords: Electromyography ; Pudendal nerve ; Neurophysiology ; Anal sphincters ; Manometry ; Cinedefecography ; Anal physiology ; Constipation ; Fecal incontinence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One hundred twenty consecutive patients with either fecal incontinence (60 patients), chronic constipation (41 patients), or idiopathic intractable pelvic pain (19 patients) were prospectively assessed. Patients underwent concentric needle electromyography (EMG), bilateral pudendal nerve terminal motor latency evaluation, anorectal manometry, and cinedefecography. The most common EMG finding in patients with fecal incontinence was decreased recruitment of motor units with squeezing and polyphasic motor unit potentials; these are consistent with an injury pattern. The most common EMG finding in the constipated patients was paradoxical puborectalis contraction. This latter abnormality was also a frequent finding in patients with rectal pain, as was prolongation of pudendal nerve latency. Paradoxical puborectalis contraction was diagnosed more frequently with EMG than with cinedefecography. Inter-examination correlation was best in the incontinent group between EMG and manometry. Cinedefecography had poor correlation with EMG in all patient groups but was valuable in the detection of additional pathology such as rectoanal intussusception and anterior rectocele. Electromyography including pudendal nerve terminal motor latency assessment is a valuable adjunct in the evaluation of disorders of evacuation. The information it yields is complementary to that offered by more routine physiologic examinations.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 34 (1991), S. 851-856 
    ISSN: 1530-0358
    Keywords: Constipation ; Colonic inertia ; Colectomy ; Colonic dysmotility ; Slow transit constipation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The results of total abdominal colectomy (TAC) with ileorectal anastomosis as a treatment for colonic inertia (CI) were prospectively assessed. One hundred sixtythree patients were evaluated for chronic constipation between July 1988 and November 1990. Patients underwent pancolonic transit times, anorectal manometry, cinedefecography (CD), and electromyography (EMG). CI was defined as diffuse marker delay on transit study without evidence of puborectalis contraction on CD or EMG. Sixteen patients (10 percent; 15 females and 1 male) with a mean age of 45 years (range, 24–75 years) with CI underwent TAC. Preoperative bowel frequency ranged from three per week to one per month; all 16 patients evacuated only with high doses of laxatives, enemas, or both. TAC was performed with no postoperative mortality or major morbidity; three patients were readmitted four times for successful conservative treatment of partial small bowel obstruction. At a mean followup of 15 months (range, 2–35 months), these 16 patients reported a mean frequency of spontaneous bowel evacuations of 3.5 per day (range, one to six per day). Patient satisfaction with the operation was “excellent” or “good” in 15 cases (94 percent). Thorough preoperative physiologic evaluation permits the selection of a small group of patients with CI who may benefit tremendously from TAC.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of chemical ecology 20 (1994), S. 3207-3219 
    ISSN: 1573-1561
    Keywords: Aggregation pheromone ; triene ; tetraene ; hydrocarbon ; Coleoptera ; Nitidulidae ; Carpophilus davidsoni ; Australian sap beetle ; trapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A male-produced aggregation pheromone was identified for the Australian sap beetle,Carpophilus davidsoni Dobson (Coleoptera: Nitidulidae), by bioassay-guided fractionation of volatiles collected from feeding beetles. The most abundant components were: (2E,4E,6E)-5-ethyl-3-methyl-2,4,6-nonatriene, (3E,5E,7E)-6-ethyl-4-methyl-3,5,7-decatriene, (2E,4E,6E,8E)-3,5,7-trimethyl-2,4,6,8-undecatetraene, and (2E,4E,6E,8E)-7-ethyl-3,5-dimethyl-2,4,6,8-undecatetraene. The relative abundance of these components in collections from individual males feeding on artificial diet was 100:7:9:31, respectively. Pheromone production began within several days after males were placed onto diet medium and continued for at least 20 weeks. Peak production was 〉3 µg total pheromone per male per day. Males in groups of 50–60 emitted less pheromone (the peak level was 0.09 µg per beetle per day), and the emissions from groups contained relatively little tetraene (proportions of the components listed above were 100:7:2:7, respectively). Three additional trienes and one additional tetraene were identified in minor amounts; the entire eight-component male-specific blend is qualitatively identical and quantitatively similar to that of the North American sibling species,C. freemani Dobson. A synthetic blend of the four major components on rubber septa, prepared to emit in the same proportions as from individual males, was highly attractive in the field when synergized with fermenting whole-wheat bread dough. Cross-attraction was observed in the field involving the pheromones ofC. davidsoni, C. hemipterus (L.), andC. mutilatus Erichson. Potential uses of the pheromones in pest management are discussed.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Laser light-scattering has been used to investigate the size of native proteoglycan aggregates (PGA-aA1) from day-8 chick limb-bud chondrocyte cultures isolated under associative extraction and purification conditions in 0.4M guanidinium chloride (GdnHCl) solution. Dynamic light-scattering measurements yielded a hydrodynamic radius, Rs, of 244 ± 10 nm for PGA-aA1 in 0.4M GdnHCl, and a weight-average molecular weight (Mw) of 150 ± 50 × 106 was obtained from a Zimm plot. Disaggregation in 4.0M GdnHCl aqueous solution yielded proteoglycan subunits (PGS) with Rs = 39 ± 2 nm, Mw = 1.6 ± 0.3 × 106, which reassembled in 0.4M GdnHCl to form “reconstituted native” aggregates (PGA-raA1) with Rs = 121 ± 6 nm, Mw = 17 ± 3 × 106. A second specimen of PGA-aA1 had Rs = 192 ± 10 nm, Mw = 100 ± 10 × 106. The latter value was estimated from an empirical relationship between Mw and Rs. After dissociation, this specimen reassembled to form PGA-raA1 with Rs = 85 ± 5 nm, Mw = 12 ± 1 × 106. These data are compared with those for a specimen of reconstituted aggregate (PGA-A1) that had been extracted under dissociative conditions and then reaggregated by dialysis to 0.4M GdnHCl aqueous solution, for which Rs = 138 ± 9 nm, Mw = 45 ± 8 × 106. From these values, we have calculated the weight-average number of subunits per aggregate Nw: 111 for PGA-aA1 and 12 for raA1 (70 and 7 for the second PGA-aA1 and PGA-raA1 specimen, respectively) as compared to 32 for PGA-A1. The numbers of subunits per aggregate were also determined from electron micrographs of spread specimens. The latter results show the same trends as those obtained by light scattering, but lead in each case to lower numbers of subunits per aggregate. These data demonstrate conclusively that PGA samples exhibit a higher degree of aggregation in solution than visualized in typical electron microscopy (EM) preparations, probably due to disaggregation during EM specimen preparation. Since Nw determined both by light scattering (LS) and by EM are larger for native versus reconstituted aggregate samples, our data point to a more compact aggregation of subunits along the hyaluronic acid (HA) chains in the former.
    Additional Material: 7 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 175 (1974), S. 3461-3473 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Polymerisation von Äthylen unter Verwendung eines mit Magnesium reduzierten Titantrichlorid-Katalysators, zusammen mit gewöhnlichen Aluminiumalkyl-Aktivatoren, wird beschrieben. Die bereits berichtete hohe Aktivität dieses Katalysatortyps wird bestätigt. Bei 50°C und 1 Atm. (1,01325 bar) Druck wird ein Wert für die Aktivitätskonstante von 3,4.106 g dm3 (mol TiCl3)-1 h-1 erhalten. Dieser Wert ist ungefähr 102 mal höher als derjenige eines auf übliche Weise mit Aluminium reduzierten Titantrichlorids. Die Viskosotäts-Molekulargewichts-Zeit (oder Umsatz)-Beziehungen sind nicht sehr verschieden von denen, die mit den üblichen Katalysatoren erhalten werden. Die Analyse der Resultate weist darauf hin, daß ein großer Teil (z. B. 50%) der Titan-Atome im Titantrichlorid, das mit Magnesium reduziert wurde, als aktive Zentren fungieren.
    Notes: The polymerisation of ethylene using magnesium reduced titanium trichloride catalysts, together with the usual aluminium alkyl activators is described. The previously reported high activity of this type of catalyst was confirmed. At 50°C and 1 atm. (1,01325 bar) pressure a value of 3,4.106 g dm3 (mol TiCl3)-1h-1 was obtained for the activity constant, a value about 102 times larger than for a conventional aluminium reduced TiCl3. On the other hand the viscosity-molecular weight-time (or conversion) relations are not very different from those given by conventional catalysts. Analysis of the results suggests that a high proportion (e.g. 50%) of the titanium atoms in the magnesium reduced TiCl3 functions as active sites.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 194 (1993), S. 2907-2922 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Ring-opened metathesis polymers of 7-methylnorbornadiene (1) have been synthesized with cis main-chain double bond contents ranging from 20 to 97% using several initiators; their microstructures have been examined in detail using 13C NMR spectroscopy. The result show that polymerization from the anti-exo orientation is greatly favoured over the syn-exo mode. A nonbonded repulsion energy of 6-8 kJ · mol-1 between the syn-7-methyl group and the double bond is estimated. The microstructural features also resemble those for polymers of the anti- and syn-7-methylnorbornenes, in contrast to poly(norbornadiene) itself and to poly(norbornene), in that the splitting of a given resonance due to tacticity effects is of the same order as splittings due to neighbouring double bonds. Cis double bond contents and tacticities using different catalysts agree well with those expected from previous work with norbornadiene and several methyl-substituted norbornenes, respectively, as monomers. The previous surprising observation that there is significantly less or no discrimination between the syn- and anti-orientations in polymerizing 7-tert-butoxy- and 7-acetoxynorbornadiene is discussed and is attributed to a pseudo [3 + 2] transition state replacing the normal one for [2 + 2] metallacyclobutanation. In the [3 + 2] mode a lone pair of electrons on the oxygen acts in conjunction with the π pairs of the C=C and [Mt]=C moieties. The net effect is to lower the energy barriers for the [2 + 2] cycloaddition and the reverse step. The same explanation, rather than chelation, is also believed to be correct for the beneficial effect on the metathesis polymerization of the 7-oxa group in several substituted 7-oxanorbornenes and 7-oxanorbornadienes when compared to the corresponding 7-methylene monomers.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 993-995 
    ISSN: 0887-624X
    Keywords: metathesis ; regioselective polymerization ; 7-alkylnorbornenes ; ab initio MO Calculations ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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