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  • 1
    Electronic Resource
    Electronic Resource
    Evidence of an aggregation pheromone in the flea beetle,Phyllotreta Cruciferae (Goeze) (Coleoptera: Chrysomelidae) (1992)
    Springer
    Journal of chemical ecology 18 (1992), S. 875-884 
    Details
    ISSN: 1573-1561
    Keywords: Aggregation pheromone ; olfactometer ; field trapping ; Coleoptera ; Chrysomelidae ; Phyllotreta cruciferae ; Brassica napus ; crucifer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Laboratory olfactometer bioassays and field trapping experiments showed that the flea beetle,Phyllotreta cruciferae (Goeze), was highly attracted by oilseed rape(Brassica napus L.) when flea beetles were on the plant. This attraction was mediated by a flea beetle-produced aggregation pheromone based upon: (1) Oilseed rape damaged mechanically, or byP. cruciferae, or by diamondback moth,Plutella xylostella (L.), did not attractP. cruciferae. (2) Contact with the plants or feeding was required for the production of aggregation pheromone because oilseed rape alone was not attractive when separated from flea beetles by a screen. (3) Equal numbers of males and females were attracted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00988328
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: Application of a stochastic model to the rat hindlimb (1996)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 24 (1996), S. 173-196 
    Details
    ISSN: 1573-8744
    Keywords: stochastic model ; transit time distribution ; tissue diffusion ; distribution kinetics ; isolated perfused hindlimb ; lidocaine ; multiple indicator dilution ; physiological pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A stochastic theory of drug transport in a random capillary network with permeation across the endothelial barrier is coupled with a model of tissue residence time of drugs assuming radial intratissue diffusion. Axial diffusion is neglected both in tissue as well as in the radially well-mixed vascular phase. The convective transport through the microcirculatory network is characterized by an experimentally determined transit time distribution of a nonpermeating vascular indicator. This information is used to identify three adjustable model parameters characterizing permeation, diffusion, and steady-state distribution into tissue. Predictions are made for the influence of distribution volume, capillary permeability, and tissue diffusion on transit time distributions. The role of convection (through the random capillary network), permeation, and diffusion as determinants of the relative dispersion of organ transit times has been examined. The relationship to previously proposed models of capillary exchange is discussed. Results obtained for lidocaine in the isolated perfused hindleg in rats indicate that although the contribution of intratissue diffusion to the dispersion process is relatively small in quantitative terms, it has a pronounced influence on the shape of the impulse response curve. The theory suggests that the rate of diffusion in muscle tissue is about two orders of magnitude slower than in water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02353488
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hemodynamic influences upon the variance of disposition residence time distribution of drugs (1983)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 11 (1983), S. 63-75 
    Details
    ISSN: 1573-8744
    Keywords: physiological pharmacokinetic model ; hemodynamics ; moments ; MDRT ; VDRT ; circulation time ; lidocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A recirculation model of drug disposition is used to interpret the physiological meaning of the variance of residence time distribution (VDRT). The pharmacokinetic parameter VDRT is determined by the means and variances of the transfer times across the organs, as well as by the respective blood flow and extraction ratios. The model is illustrated for a specified distribution of organ transit times assuming flow limited mass transport. Based on data from the literature, the influence of changes in cardiac output and its regional distribution on the variance of recirculation and residence times, respectively, is predicted for lidocaine. Thereby the study is focused on the effect of certain cardiovascular states (shock, hypoxia, exercise, sympathomimetic drugs). Unlike pharmacokinetic parameters derived from the zeroth and first curve moments, the relative residence time dispersion is found to be affected by a redistribution of the blood flow among the noneliminating organs. The equations presented allow a simple and rapid calculation of clinically relevant pharmacokinetic parameters from physiological and physicochemical data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061768
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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