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  • Colias  (2)
  • Key words: TCR — V-gene — Nucleotide differences — Alpha chain — Beta chain — Evolutionary preservation  (1)
  • Neutrophils  (1)
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Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Profile of Numbers of Sequence Differences Among V-Genes Coding for the Variable Regions of T Cell Receptor for Antigen Alpha and Beta Chains (1997)
    Springer
    Journal of molecular evolution 44 (1997), S. 253 -257 
    Details
    ISSN: 1432-1432
    Keywords: Key words: TCR — V-gene — Nucleotide differences — Alpha chain — Beta chain — Evolutionary preservation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. When human T cell receptor for antigen (TCR) alpha chain V-genes were compared pair-wise, the numbers of nucleotide differences showed a characteristic distribution; most were in the range of 100 to 200 differences out of a total of about 300 bases. The same distribution was observed for mouse TCR alpha chains. Even more interesting was that comparing human alpha chains and mouse alpha chains gave essentially the same nucleotide difference pattern. It is inferred from the large number of differences and from the nonspecificity of trans-species (human and mouse) nucleotide sequence differences of TCR V-genes that TCR alpha chains probably diverged early during evolution. The same feature was also observed for human and mouse TCR beta chains, although the alpha and beta chain V-genes were distinct. This evolutionary preservation could be of vital importance to the fidelity of the complicated trimolecular interactions among TCR alpha and beta chains, the processed peptide, and the major histocompatibility complex (MHC) class I or II molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006142
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Superoxide anion production by rat neutrophils at various stages of bleomycin-induced lung injury (1992)
    Springer
    Lung 170 (1992), S. 41-50 
    Details
    ISSN: 1432-1750
    Keywords: Superoxide ; Neutrophils ; Bleomycin-induced lung injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study investigated the level of activation of neutrophils isolated from rats at various stages of bleomycin-induced lung injury. Neutrophils were collected from blood and bronchoalveolar lavage (BAL) fluid and their superoxide anion (O f2 p− )-generating capacity measured in response to phorbol myristate acetate (PMA) and opsonized zymosan (OZ) stimulation. When stimulated with PMA, BAL neutrophils isolated from animals 3 days after bleomycin treatment had a significantly greater capacity to produce O f2 p− than BAL neutrophils from animals 7 days after bleomycin treatment. The O f2 p− levels of 7 day BAL neutrophils more closely resembled the resting levels obtained with circulating neutrophils from both control and bleomycin-treated animals. There were no differences observed in any of the neutrophils when stimulated with OZ. Myeloperoxidase levels were measured in plasma and BAL and found to be elevated only in plasma at 7 days after bleomycin. These data demonstrate that neutrophil activation does occur in this model and that the activation appears to be transient, in response to specific stimuli and compartmentalized between the lung and blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164754
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Polymorphism and predictability at the α-glycerophosphate dehydrogenase locus in Colias butterflies: Gradients in allele frequency within single populations (1976)
    Springer
    Biochemical genetics 14 (1976), S. 403-426 
    Details
    ISSN: 1573-4927
    Keywords: polymorphism ; Colias ; α-glycerophosphate dehydrogenase ; cline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Heterozygosity at the α-glycerophosphate dehydrogenase locus of five species of Colias butterflies is widespread in montane populations; alpine and lowland populations are not heterozygous. Within a single demographically characterized population of C. meadii where the population extends from alpine down into montane habitats, a marked cline in allele frequency is seen. Such within-population clines suggest the involvement of strong selection across the marked ecological interface. Thermal factors are the most likely causative agents, but associative overdominance is not excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486123
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of electrophoretically cryptic variation in the alpine butterfly Colias meadii (1977)
    Springer
    Biochemical genetics 15 (1977), S. 665-693 
    Details
    ISSN: 1573-4927
    Keywords: Colias ; enzyme polymorphism ; protein conformation ; electrophoresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Enzyme polymorphism was characterized among the proteins of 14 loci of Coliae meadii by replicate electrophoresis in polyacrylamide gels of differing pore size. The results reveal a large number of variants, with a very skewed frequency distribution. A large fraction of the variants cannot be differentiated by electrophoresis in 5–7% acrylamide gels. This gel sieving approach permits an estimate of the relative contributions of charge and of conformation to electrophoretic mobility. Many of the variant proteins do not differ in charge. Most variants exhibit different degrees of interaction with the gel and presumably differ in conformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484097
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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