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  • 1
    Digitale Medien
    Digitale Medien
    Presence of type III collagen in bone from a patient with osteogenesis imperfecta (1977)
    Springer
    European journal of pediatrics 125 (1977), S. 29-37 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Osteogenesis imperfecta ; Collagen types ; Bone ; In vitro study ; Immunofluorescence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Samples of bone from a patient with osteogenesis imperfecta were found to synthesize and contain type III collagen as well as type I collagen. Normal bone contains only type I collagen except in the lining cells of the bone marrow cavities. In the patient's tissue, type III collagen was localized in nonfibrillar structures in discrete areas of the bone. These and previous studies indicate that certain types of osteogenesis imperfecta may be caused by a failure of normal bone maturation and the sites in which the type III collagen is found appear to be defects in the bone.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00470603
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Progeria: A cell culture study and clinical report of familial incidence (1977)
    Springer
    European journal of pediatrics 124 (1977), S. 101-111 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Hutchinson-Gilford-syndrome ; Familial incidence ; Autosomal-recessive disorder ; Fibroblast cultures ; Collagen types ; Thymidine incorporation ; Immunofluorescence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This report relates the case histories of two sisters who demonstrated the typical symptoms of progeria at birth. One of these children had died previous to this study. The familial occurrence underlines the thesis that progeria is an autosomal-recessive disorder. The examination of the cultured skin fibroblasts from the younger child showed a clear decrease in cell growth. On the other hand, the immunfluorescent examination of skin biopsies and cultured skin fibroblasts revealed no atypical distribution of collagen types.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00477545
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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