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  • Collision tumors  (1)
  • Cytology  (1)
  • Differentiation  (1)
  • Esthesioneuroblastoma  (1)
  • Glial fibrillary acidic protein  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Esthesioneuroblastoma: Ultrastructural, immunohistological and biochemical investigation of one case (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 133-144 
    Details
    ISSN: 1434-4726
    Keywords: Esthesioneuroblastoma ; Intermediate filaments ; Secretory granules ; Ultrastructure ; Immunohistology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of esthesioneuroblastoma, the pathological diagnosis of which almost always causes great difficulties, was investigated ultrastructurally, biochemically, and immunohistologically, using antibodies against the five known types of intermediate filaments [keratin, vimentin, desmin, glial fibrillary acidic protein (GFAP) and neurofilaments]. The tumour cells did not react with antibodies against any of the five intermediate filament proteins. Ultrastructural investigations showed dense cored secretory granules in the cytoplasm and cell processes. Thus, immunohistology offers by “exclusion” a differential diagnosis to avoid often misdiagnosed tumours (undifferentiated carcinomas, embryonal rhabdomyosarcomas, and malignant lymphomas), since carcinomas react with antikeratin, embryonal rhabdomyosarcomas with antibodies to desmin and malignant lymphomas show immunofluorescence with antibodies to vimentin. The biological behaviour (age distribution, tendency to metastasize), the normal values of biochemical parameters, homovanillic acid and vanilmandelic acid (HVA, VMA), and the absence of neurofilaments distinguish this type of tumour from the peripheral sympathetic neuroblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463554
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diagnostic value of intermediate filament antibodies in clinical cytology (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 114-123 
    Details
    ISSN: 1432-1440
    Keywords: Cytology ; Imprints ; Human tumors ; Cytokeratin ; Vimentin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies to intermediate filament (IF) proteins can distinguish the major tumor groups as shown by results with sectioned human material. In this study we evaluate the use of similar methods in the cytology of human tumors. Smears obtained from fine needle aspiration biopsies were investigated using well characterized antibodies, each specific for only one of the five types of intermediate filaments. Tumor cells of different carcinomas, thymomas, and the epithelial part of pulmonary blastomas were positive with antibodies recognizing cytokeratins. Tumor cells in non-muscle sarcomas, including lymphoma and Ewing's sarcoma, could be specifically identified with antibodies to vimentin. Tumor cells of muscle sarcomas were desmin-positive. Finally, tumor cells in pheochromocytoma and bronchus carcinoid were positive with antibodies specific for neurofilaments. Specimens were also examined in parallel using conventional cytochemical stains, such as May-Grünwald-Giemsa. In addition, in most cases sections of the tumor were examined both by histology and IF typing of frozen sections to confirm the diagnosis made on the cytologic specimens. The results show that IF typing is a valuable diagnostic aid in clinical cytology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01738701
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Osteoclast-type giant cell tumour of the pancreas (1988)
    Springer
    Virchows Archiv 412 (1988), S. 247-253 
    Details
    ISSN: 1432-2307
    Keywords: Pancreatic osteoclast-type giant cell tumour ; Differentiation ; Histogenesis ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases of osteoclast-type giant cell tumour of the pancreas (OGTP) are presented and compared with similar tumours of other locations and pancreatic carcinomas. One of the tumours was analyzed by immunohistochemical methods. The mononuclear stromal cells and osteoclast-like giant cells, which characterize this very rare neoplasm, reacted with an antibody against vimentin, but were not decorated by antibodies against lysozyme, alpha-1-ACHT, alpha-1-AT. Pleomorphic mononuclear cells in osteoid additionally contained osteonectin and could thus be identified as osteoblasts. Only the tumour glands stained positively with panepithelial keratin antibodies and antibodies against the keratin polypeptides 7, 18, 19. These results demonstrate for the first time the mesenchymal differentiation of the OGTP, which in some cases is also able to form epithelial structures. The immunohistochemical reactions and the characteristic morphology of the tumour show the OGTP to be an entity which must be differentiated from pancreatic carcinoma, especially from its giant cellular subtype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00737149
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Metastasis of renal carcinoma colliding with glioblastoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 448-452 
    Details
    ISSN: 1432-0533
    Keywords: Collision tumors ; Metastasis of cancer to cancer ; Glial fibrillary acidic protein ; Cytokeratins ; Brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report presents the case of a 74-year-old woman who was simultaneously affected by two highly malignant neoplasms, a metastasizing renal cell carcinoma and a glioblastoma with sarcomatous component. Leptomeningeal metastasis of renal carcinoma is shown to invade the glioblastoma at its margin. Especially in gliomas, “cancer to cancer” phenomenoma are only rarely documented. Support by immunohistochemical data may prove those events to be more frequent than assumed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307701
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    Paper (German National Licenses)
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