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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 20 (1999), S. 351-354 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Malakoplakie ; Kolon ; Intestinale Blutung ; Key words Malakoplakia ; Colon  ;  Intestianal Bleeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on a 62-year-old female patient with melena in which polypoid lesions of the cecum were discovered endoscopically. Histological examination of mucosal biopsies revealed an inflammatory process with lots of histiocytes and so-called Michaelis-Gutmann bodies, leading to the diagnosis of a malakoplakia of the colon. No other organs were found affected. In the course of an antibiotic therapy, there was no melena detectable over a period of six months. Malakoplakia, an inflammation usually affecting the urogenital tract, is rarely found in the colon, with only 35 cases published until now. It is frequently associated with other diseases like neoplastic or inflammatory disorders, immune defect syndromes or heroin abuse. This spectrum is expanded by our report in which a long-standing alcohol abuse was found as an attendant disease.
    Notes: Zusammenfassung Es wird der Fall einer 62jährigen Patientin vorgestellt, bei der anläßlich einer aufgrund von Teerstühlen durchgeführten Koloskopie polypöse Schleimhautvorwölbungen im Zäkum festgestellt und biopsiert wurden. Histologisch zeigte sich eine histiozytenreiche Entzündung mit Nachweis sog. Michaelis-Gutmann-Körperchen im Sinne einer Malakoplakie. Es wurden keine anderweitigen Organmanifestationen dieser Erkrankung gefunden. Nach Einleitung einer antibiotischen Therapie wurden innerhalb eines Beobachtungszeitraums von 6 Monaten keine Teerstühle mehr festgestellt. Das Kolon stellt einen ungewöhnlichen Manifestationsort der üblicherweise im Urogenitaltrakt auftretenden Malakoplakie mit bisher erst 35 Fälle publizierten Fälle dar. Häufig ist die Malakoplakie mit anderen Grunderkrankungen (z. B. Neoplasien, Infektionskrankheiten, Autoimmunerkrankungen, Immundefekten, Heroinabusus) assoziiert. Dieses Spektrum wird durch den vorliegenden Fall ergänzt, in dem ein langjähriger Alkoholabusus als Begleiterkrankung vorlag.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1615-6102
    Keywords: Glutathione ; Plasma membrane redox acitvity ; Electron transfer ; Zea mays ; Diamide ; Buthionine-D,L-suIfoximine ; Hexacyanoferrate III ; Hexabromoiridate IV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We investigated changes of thiols (GSH, GSSG, and cysteine) induced by transplasma membrane electron transport after addition of artificial electron acceptors and the influence of the thiol level on redox activity. GSH, GSSG, and cysteine content of maize (Zea mays L. cv. Golden Bantam) roots and coleoptile segments was determined by high performance liquid chromatography with a fluorescence detector. GSSG increased after treatment with 0.8 mM diamide, an SH-group oxidizer. GSH level of roots increased after treatment with diamide, while GSH levels of coleoptiles decreased. Incubation of roots with the GSH biosynthesis inhibitor buthionine-D,L-sulfoximine for 6 days lowered the glutathione level up to 80%. However, the GSH/GSSG ratio of maize roots remained constant after treatment with both effectors. The GSH/GSSG ratio and the glutathione level were changed by addition of artificial electron acceptors like hexacyanoferrate (III) or hexabromoiridate (IV), which do not permeate the plasma membrane. Hexacyanoferrate (III) reduction was inhibited up to 25% after the cellular glutathione level was lowered by treatment with diamide or buthionine-D,L-sulfoximine. Proton secretion induced by reduction of the electron acceptors was not affected by both modulators. The change in glutathione level is different for roots and coleoptiles. Our data are discussed with regard to the role of GSH in electron donation for a plasma membrane bound electron transport system.
    Type of Medium: Electronic Resource
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