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  • Column liquid chromatography  (2)
  • Neuropil threads  (2)
  • [abr] pCMB; p-chloromercuric benzoate  (2)
  • 1
    Electronic Resource
    Electronic Resource
    In vitro autodegradation of ribosomal RNA formation of specific fragments with endonucleolytic cleavages
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 62 (1975), S. 176-183 
    Details
    ISSN: 0006-291X
    Keywords: [abr] SDS; sodium dodecylsulfate ; [abr] pCMB; p-chloromercuric benzoate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(75)80120-3
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro autodegradation of ribosomal RNA formation of specific fragments with endonucleolytic cleavages
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 62 (1975), S. 176-183 
    Details
    ISSN: 0006-291X
    Keywords: [abr] SDS; sodium dodecylsulfate ; [abr] pCMB; p-chloromercuric benzoate
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0006-291X(75)80120-3
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 368-374 
    Details
    ISSN: 1432-0533
    Keywords: Neuropil threads ; Alzheimer-type dementia ; tau protein ; Palred helical filaments ; Senile plaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thread-like structures immunoreactive with paired helical filaments and tau antisera were demonstrated as mesh-works in the neocortices of five brains with Alzheimer-type dementia, but not in those of five normal aged control brains. The ultrastructure of the threads was examined using paired routine electron microscopic ultrathin sections and adjacent 0.4-μm-thick semithin sections, immunostained for β protein. Outside the β protein-positive senile plaques, neuropil threads appeared sporadically as small slender neurites, containing either regularly constricted or straight filaments. These neurites often showed dendritic profiles. Similar threads were also seen within the senile plaques. The threads were accumulated in amyloid fibril-rich primitive plaques, but not in amyloid fibril-poor diffuse plaques. The presence of these threads was closely associated with neurofibrillary tangle formation. Our findings suggest that wide-spread change of the neuropil neurites, neuropil threads or curly fibers, both outside and inside of the senile plaques are dendritic in origin and play an important role in the clinical manifestation of dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307689
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 603-609 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer-type dementia ; Neurofibrillary tangles ; Neuropil threads ; Amyloid β/A4 protein ; Astroglia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the cellular components of extracellular neurofibrillary tangles (E-NFT) in the hippocampal areas in cases with Alzheimer-type dementia. Immunohistochemically, the E-NFT were labeled for the C terminus of tau and glial fibrillary acidic protein. Moreover, the majority of the E-NFT was associated with intensely argyrophilic rods and with tau-and ubiquitin-immunoreactive dots. Ultrastructurally, the E-NFT consisted mainly of extracellular paired helical filaments (PHF) and astroglial processes. The extracellular PHF tended to be straighter and thinner. One third of the E-NFT was associated with small degenerating neurites containing many dense bodies and with neuropil threads containing PHF. These findings suggested that extracellular PHF promote both intense astroglial reaction and neuritic alteration, and that the E-NFT are continuously changing their morphology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296369
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Direct enantiomeric separation of racemic precursors to diltiazem hydrochloride and clentiazem maleate by HPLC on a chiral ovomucoid column (1993)
    Springer
    Chromatographia 35 (1993), S. 305-310 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Enantiomer separation ; Chiral ovomucoid column ; Diltiazem hydrochloride ; Clentiazem maleate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A direct HPLC separation method was developed for the determination of the enantiomers of racemic precursors to diltiazem (I) and its 8-chloro derivatives (II). The enantiomers were successfully separated on a chiral ovomucoid column using an aqueous-organic mobile phase (reversed-phase HPLC). The influence of the organic modifier and buffer pH on the retention and enantioselectivity was investigated. The chromatographic conditions chosen for the separation permitted complete resolution of the enantiomers of both the acid (Ib and IIb) and methyl ester precursors (Ia and IIa) within 20 min. The influence of sample load on retention times, theoretical plates numbers, peak heights and peak areas was also investigated. The peak areas showed a good linearity over the concentration range examined, although all the others were influenced significantly by the sample size. An optical antipode of the intermediate to be determined could be detected by the area-percentage method down to ca. 0.1%, together with the determination of its precursor, including its optical purity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02277515
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Reversed-phase HPLC separation of the enantiomers of denopamine after derivatization with GITC chiral reagent (1990)
    Springer
    Chromatographia 30 (1990), S. 186-190 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Enantiomer separation ; Denopamine ; Derivatization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A reversed-phase high-performance liquid chromatographic (HPLC) method was developed to determine the optical purity of denopamine, which is a new cardiotonic agent having an asymmetric carbon in a molecule. The enantiomers were converted to diastereomeric thiourea derivatives using 2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate (GITC) reagent. Separation of the enantiomers of denopamine as diastereomers was successfully achieved by reversed-phase HPLC within 10 min using an ODS column and UV detection. Derivatization of denopamine proceeded rapidly under the alkaline conditions and the ambient temperature. This method was applied to the determination of the optical purity of denopamine drug substances and those in tablets. The favorable UV absorption of the derivatives enabled the optical antipode to be determined down to the 0.2% level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274544
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    Paper (German National Licenses)
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