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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 27 (1999), S. 648-655 
    ISSN: 1573-9686
    Keywords: Leukocyte model ; Computational cellular dynamics ; Cell recovery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The rheological properties of a leukocyte significantly affect its biological and mechanical characteristics. To date, existing physical models of leukocyte are not capable of quantitatively explaining the wide range of deformation and recovery behaviors observed in experiment. However, a compound drop model has gained some success. In the present work, we investigate the effect of nucleus size and position, and the relative rheological properties of cytoplasm and nucleus, on cell recovery dynamics. Two nucleus sizes corresponding to that of neutrophil and lymphocyte are considered. Direct comparison between numerical simulations and experimental observation is made. Results indicate that the time scale ratio between the nucleus and cytoplasm plays an important role in cell recovery characteristics. Comparable time scales between the two cell components yield favorable agreement in recovery rates between numerical and experimental observations; disparate time scales, on the other hand, result in recovery behavior and cell shapes inconsistent with experiments. Furthermore, it is found that the nucleus eccentricity exhibits minimum influence on all major aspects of the cell recovery characteristics. The present work offers additional evidence in support of the compound cell model for predicting the rheological behavior of leukocytes. © 1999 Biomedical Engineering Society. PAC99: 8717-d, 8719Tt
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 1231-1261 
    ISSN: 0029-5981
    Keywords: float zone ; crystal growth ; solidification ; moving boundary ; thermocapillary transport ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A computational capability has been developed to predict the free surface shape, heat transfer and melt-crystal interface shapes in float-zone processing. A moving boundary, second order, finite volume, incompressible Navier-Stokes solver has been developed for the fluid flow and heat transfer calculations. The salient features of the approach include solving the dynamic form of the Young-Laplace equation for the free surface shape, dynamic remeshing to fit the free boundary, a flexible, multi-block, grid generation procedure and the enthalpy method to capture the melt-crystal and the melt-feed interfaces without the need for explicit interface tracking. Important convective heat transfer modes; natural convection and thermocapillary convection have been computed. It is shown that, whereas the overall heat transfer is not substantially affected by convection, the melt-crystal interface shape acquires significant distortion due to the redistribution of the temperature field by the thermocapillary and buoyancy-induced convective mechanisms. It is also demonstrated that the interaction of natural and thermocapillary convection can reduce the melt-crystal interface distortion if they act in opposing directions. It is found that the meniscus deformation can cause the height of the zone to increase but the qualitative nature of the melt-solid interface shapes are not significantly affected. Results are compared with literature to validate the predictive capability developed in this work. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 23 Ill.
    Type of Medium: Electronic Resource
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