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  • Congenital nephrotic syndrome  (1)
  • Lectin histochemistry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Proteinuria in a child with sialidosis: Case report and histological studies (1989)
    Springer
    Pediatric nephrology 3 (1989), S. 166-174 
    Details
    ISSN: 1432-198X
    Keywords: Sialidosis ; Proteinuria ; Lectin histochemistry ; Visceral epithelial cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 9-year-old body with sialidosis had nephrotic-range proteinuria. Histological studies demonstrated massive distension of renal cells, particularly glomerular visceral epithelial cells, by cytoplasmic vesicles which contained material reactive with concanavalin A and wheat-germ agglutinin. In addition, some glomeruli exhibited segmental mesangial thickening or glomerulosclerosis. Ultrastructurally, focal detachment of visceral epithelial cells from the underlying glomerular basement membrane was observed. We postulate that glomerular visceral epithelial cell dysfunction may underlie the proteinuria and focal glomerulosclerosis exhibited by this patient. Hyperfiltration, as suggested by the child's elevated creatinine clearances, may be a contributing factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00852901
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Steroid-dependent nephrotic syndrome following renal transplantation for congenital nephrotic syndrome (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 300-303 
    Details
    ISSN: 1432-198X
    Keywords: Congenital nephrotic syndrome ; Nephrotic syndrome ; Renal transplant ; Soluble immune response suppressor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A boy developed recurrent steroid-responsive nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. The first episode was associated with mild tubulointerstitial rejection on kidney biopsy. Subsequent episodes showed normal histology by light microscopy and epithelial foot process fusion on electron microscopy, consistent with minimal change nephrotic syndrome. Serum analysis for soluble immune response suppressor was negative pre-nephrectomy, positive during each bout of nephrotic syndrome, and negative during each remission. This case represent de novo occurrence of steroid-sensitive minimal change nephrotic syndrome following renal transplantation for congenital nephrotic syndrome. We stress the need for histological examination of the renal allograft to diagnose rejection, recurrent disease, or de novo disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00867484
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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