ISSN:
1432-1912
Keywords:
Adenosine analogues
;
Conscious dogs
;
Glucagon release
;
Insulin release
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An investigation was carried out in conscious dogs concerning the effects of three adenosine derivatives substituted at the 5′-(744-96) or 2′-, 3′-, and 5′-positions (744–98, 744–99), with pronounced and long-lasting coronary dilator activity, on glucagon release. All three compounds (10 μg/kg i.v.) induced a sustained increase in plasma glucose and a decrease in plasma FFA concentration; concomitantly, plasma glucagon levels rose 2–3 fold. Changes in plasma insulin concentration were relatively small and of no statistical significance. A simultaneous fall in arterial blood pressure was also observed. A lowering of blood pressure of similar magnitude by sodium nitroprusside infusion in control experiments failed to show any significant effect on plasma glucagon level. These results point to a specific effect of vasoactive adenosine derivatives on glucagon release.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00507965
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