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  • Conversion to lysophospholipid renin inhibitor  (1)
  • Idiopathic nephrolithiasis  (1)
  • 1
    Digitale Medien
    Digitale Medien
    A possible role of the kidney in activating a renin preinhibitor (1975)
    Springer
    Research in experimental medicine 166 (1975), S. 201-207 
    Details
    ISSN: 1433-8580
    Schlagwort(e): Phospholipid renin preinhibitor ; Conversion to lysophospholipid renin inhibitor ; Human plasma ; Human kidney homogenate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to verify the possibility than human plasma and kidney can activate a renin preinhibitor (Phospholipid) into inhibitor (lysophospholipid), constant quantities of preinhibitor were added to plasma and kidney homogenate. Addition of preinhibitor to plasma did not modify the quantity of Angiotensin I that developed. On the other hand, addition of preinhibitor to crude kidney homogenate, followed by incubation with human angiotensinogen, caused a significant fall in the quantity of Angiotensin I generated. While plasma is deficient in the specific enzyme delegated to the transformation of preinhibitor into inhibitor, it appears that this enzyme is present in the kidney.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01852632
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of the oral administration of glycosaminoglycans on cellular abnormalities associated with idiopathic calcium oxalate nephrolithiasis (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 237-240 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Idiopathic nephrolithiasis ; glycosaminoglycans ; red cell oxalate selfexchange ; red cell membrane protein phosphorylation ; Sulodexide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Oral administration of mixture of extractive glycosaminoglycans to a group of renal stone formers led to a significant decrease in oxalate self-exchange and in erythrocytes membrane protein phosphorylation traits that are abnormal in the majority of patients with idiopathic calcium nephrolithiasis. The action of glycosaminoglycans at the cellular level is probably due to their modulating activity on certain membrane protein kinases. The proven effect of the glycosaminoglycans opens a new pharmacological approach to the prevention of recurrent nephrolithiasis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00315202
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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