ISSN:
1432-1432
Keywords:
Oligonucleotide analogues having phosphoramidate backbone
;
Copolymerization
;
Template effect
;
Helix stability
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The tetranucleoside triphosphoramidates CNHpGNHpCNHpGN 3 and GNHpCNHpGNHpCN 3 do not affect the rate of condensation between dinucleoside phosphoramidates pCNHpGN 3 and CNHpGNH 2 in the presence of a water-soluble carbodiimide. This result contrasts with the previously reported efficient template-directed oligomerization of the corresponding GC dimers on the phosphoramidate-linked tetramer of sequence GCGC. These findings are discussed in terms of the relative stability of helices formed by the template itself and by the template with complementary dimers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02103614
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