ISSN:
1572-8773
Keywords:
Ascorbic acid
;
Purines
;
Oxidation
;
Antioxidants
;
Copper
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary Uric acid and other purines including 1-methyl-, 7-methyl-, and 1,7-dimethyluric acid, adenine, guanine, xanthine, hypoxanthine, purine, and the structurally similar compound allopurinol protected ascorbic acid from oxidation catalyzed by copper. If the hydrogen at either the 3 or 9 nitrogen of the uric acid was replaced by a methyl group, the compound did not protect ascorbate. 3-Ribosyluric acid, xanthosine, adenosine, and guanosine also failed to protect ascorbate. It was concluded that in order for purines to complex with copper to protect ascorbate from copper-catalyzed oxidation, the nitrogens at both positions 3 and 9 of the purine must be unsubstituted.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01129207
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