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  • Copper treatment  (1)
  • Schlüsselwörter Akutes Nierenversagen  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 152 (1993), S. 828-832 
    ISSN: 1432-1076
    Keywords: Menkes disease ; Copper treatment ; d-Penicillamine ; Dopamine-β-hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Menkes disease (MD) is an X-linked recessively inherited neurodegenerative disorder of copper (Cu) metabolism leading to death in early childhood. Symptoms are attributed to deficient activity of Cu-dependent enzymes. Limited experience has been reported concerning clinical and biochemical consequences of parenteral treatment with copper-(histidine)2-complex (Cu-His) in MD. Cu-His was administered in a 13-week-old boy with MD by daily intramuscular injections. After 6 weeks of therapy, Cu and caeruloplasmin in serum and Cu in CSF were normalized. The excessive dopamine level in CSF was corrected after 3 months of treatment. After 6 weeks of Cu supplementation, complete reduction of epileptic discharges, improved muscular tone and increased motor activities were observed. Developmental regression stopped and was replaced by a slight progression. Death at the age of 19 months was caused by septicaemia due to a fulminant urinary tract infection; there was no evidence of chronic Cu toxicity. These findings suggest that Cu-His supplementation may be a promising palliative treatment in MD.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Intensivmedizin und Notfallmedizin 36 (1999), S. 635-639 
    ISSN: 1435-1420
    Keywords: Key words Acute renal failure ; uremic encephalopathy ; emergency medicine ; benign prostatic hypertrophy ; Schlüsselwörter Akutes Nierenversagen ; urämische Enzephalopathie ; Notfallmedizin ; benigne Prostatahypertrophie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unklare Bewußtseinsstörungen sind ein häufiger Alarmierungsgrund für den Notarzt. So wurde auch im vorliegenden Fall eines 71-jährigen Patienten mit einer plötzlichen Bewußtseinstrübung der Notarzt gerufen. Als Auslöser der Bewußtseinsstörung fand sich eine urämische Enzephalopathie bei akutem Nierenversagen. Der Patient wurde auf die internistische Intensivstation aufgenommen und in den folgenden zwei Tagen dreimal hämodialysiert. Danach stabilisierte sich die Nierenfunktion. Als Ursache des renalen Versagens fand sich eine Hydronephrose bei Prostataadenom, die drei Wochen später transurethral reseziert wurde. Die Kasuistik zeigt, daß bei unklaren Bewußtseinsstörungen im Notarztdienst auch seltene metabolische Krankheitsbilder differentialdiagnostisch zu berücksichtigen sind.
    Notes: Summary Neurocognitive disorders are often the reason to call for an emergency physician. We report on a 71 year old male patient who showed a sudden sensorial clouding caused by an uremic encephalopathy. The patient was admitted to the intensive car unit. During the following two days he underwent three emergency hemodialysis sessions until renal function recovered. Further investigations revealed as hydronephrosis secondary to a benign prostatic hypertrophy as the cause of acute renal failure
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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