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  • 1
    Electronic Resource
    Electronic Resource
    Prevalence of diabetic autonomic neuropathy measured by simple bedside tests (1981)
    Springer
    Diabetologia 20 (1981), S. 190-194 
    Details
    ISSN: 1432-0428
    Keywords: IDDM ; diabetic autonomic neuropathy ; prevalence ; simple bedside tests ; nerve function ; retinopathy ; nephropathy ; diabetic complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the prevalence of diabetic autonomic neuropathy, five simple bedside tests, beat-to-beat variation during quiet respiration, beatto-beat variation during forced respiration, heart rate and blood pressure response to standing, heart rate response to exercise, and heart rate response to Valsalva's manoeuvre were applied to 75 male insulindependent diabetics, mean age 40 years, (range 30–49 years). The subjects were subdivided into three groups according to duration of diabetes, which was between 0 and 40 years. Twenty-eight healthy age-matched male controls were also studied. The prevalence of diabetic autonomic neuropathy in the whole diabetic population indicated by abnormal response in beat-to-beat variation during forced respiration was 27%. Diabetic autonomic neuropathy increased in frequency with duration of disease. Patients with nephropathy or proliferative retinopathy had a significantly higher prevalence of diabetic autonomic neuropathy as indicated by abnormal beat-to-beat variation during forced respirations (p〈0.01) than patients without these complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252626
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Increased glucose carbon recycling in severely insulin deficient Type 1 (insulin-dependent) diabetic subjects (1990)
    Springer
    Diabetologia 33 (1990), S. 158-162 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; insulin-dependent ; glucose recycling ; glucose ; insulin ; Cori cycle ; isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six Type 1 (insulin-dependent) diabetic subjects were studied in order to determine the contribution of recycling of glucose carbon to the overproduction of glucose which is characteristic of the fasting hyperglycaemia produced by insulin withdrawal. The subjects were studied on two occasions, once after an overnight insulin infusion and once following 24 h of insulin withdrawal. The difference in turnover rates of 1-14C-glucose and 3-3H-glucose was used as a measure of glucose recycling. Insulin withdrawal caused a marked metabolic derangement with a rise in non-esterified fatty acids from 0.69±0.23 to 1.11±0.21 mmol/l (mean±SEM, p〈0.05), total ketones from 0.27±0.06 to 2.06±0.51 mmol/l (p〈0.01), cortisol from 341±43 to 479±31 nmol/l (p〈0.05) and growth hormone from 1.1±0.3 to 19+5-mu/l (p〈0.05). Glucose turnover rose from 13.8±2.3 μmol·kg−1·min−1 at a glucose of 6.9±0.7 mmol/l in the insulin infused study to 25.8±4.4 μmol·kg−1·min−1 (p〈0.05) at a glucose of 16.4±0.7 mmol/l in the insulin withdrawn study. Recycling also rose from 3.0±0.4 μmol· kg−1·min−1 to 9.4±2.2 μmol·kg−1·min−1 (p〈0.05) when insulin withdrawn, accounting for 23±3% and 36±3% of glucose turnover, respectively. We conclude that in the severely insulin deficient Type 1 diabetic subject recycling of glucose carbon is a major contributor to the excess glucose production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404043
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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