ISSN:
1433-8491
Keywords:
Schizophrenic brain dysfunction
;
PET in schizophrenia
;
Motor dysfunction
;
Cortical activation in schizophrenia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Positron emission tomography (PET) and the deoxyglucose method were used to measure cerebral metabolism in 14 normals and 13 schizophrenics at rest and during performance of simple and complex finger-movement sequences. The normals, but not the schizophrenics, showed significant metabolic activation in mesial frontal and contralateral sensorimotor and premotor regions during the complex movement. The relative metabolism of schizophrenics was significantly lower than normal in frontal regions and higher than normal in thalamus and basal ganglia underall scanning conditions. The results suggest that schizophrenics may have a brain dysfunction which limits their capacity to produce a focal metabolic response to stimulation in several functionally distinct brain regions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02191884
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