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  • 1
    Digitale Medien
    Digitale Medien
    Creutzfeldt-Jakob disease with severe involvement of cerebral white matter and cerebellum (1990)
    Springer
    Virchows Archiv 417 (1990), S. 533-538 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Creutzfeldt-Jakob disease ; Cerebellar de-generation ; Leucoencephalopathy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We describe a patient with Creutzfeldt-Jakob disease (CJD) of the ataxic and panencephalopathic type. Postmortem examination revealed the characteristic lesions of CJD in the grey matter and profound white matter involvement was seen with immunocytochemical techniques. Ultrastructural white matter lesions were identical to those described in experimentally transmitted CJD. There was marked loss of cerebellar granule cells with virtual disappearance of parallel fibres, but Purkinje cells were only slightly reduced. Electron microscopic studies revealed extensive degenerative changes including cytoplasmic vacuoles in both cell types. Silver methods disclosed massive impregnation of white matter and striking abnormalities of Purkinje cells consisting of hypertrophy and flattening of thick dendritic branches, reduction in the number of terminal branchlets, segmentary loss of spines and polymorphic spines. These findings show the extensive involvement of all three cerebellar cortical layers and the reactive plasticity of Purkinje cells to deafferentiation. They favour the hypothesis that demyelination represents a primary lesion of the white matter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01625735
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Primary leptomeningeal lymphoma presenting as cerebellopontine angle lesion (1994)
    Springer
    Neuroradiology 36 (1994), S. 369-371 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Adenosine deaminase (ED 3.5.4.4.) ; Brain tumour ; Cerebellopontine angle ; Lymphoma ; Meningitis ; Tuberculosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report a primary leptomeningeal lymphoma (PLML) presenting as a cerebellopontine angle lesion. CT showed slight enlargement of the ventricular system, obliteration of the basal cisterns and a dense lesion in the left cerebellopontine angle which enhanced with contrast medium. Cerebrospinal fluid abnormalities included sterile lymphocytic pleocytosis without malignant cells, low sugar and high adenosine deaminase levels. An erroneous diagnosis of tuberulous meningitis was made, but autopsy revealed a leptomeningeal B-cell lymphoma with infiltration of the middle cerebellar peduncle giving the appearance of a cerebellopontine angle lesion. Seven cases of cerebellopontine angle lymphoma have previously been decribed, only one of which could be classified as PLML.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00612120
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Intramedullary tuberculoma of the spinal cord with syringomyelia (1996)
    Springer
    Neuroradiology 38 (1996), S. S105 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Tuberculosis ; Magnetic resonance imaging ; Spinal cord ; Syringomyelia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We describe a patient with a presumed intramedullary tuberculoma treated only with antituberculous therapy. MRI showed a ring-enhancing annular lesion in the thoracic spinal cord with a distant syringomyelic cavity, which improved after therapy. MRI in this case allowed us not only to achieve a presumptive diagnosis but also to assess the therapeutic response, making surgical exploration unnecessary.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02278132
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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