ISSN:
1432-1912
Keywords:
PGI2, PGI analogues, PGE1
;
cAMP levels
;
Isobutylmethylxanthine
;
Cultured endothelial and smooth muscle cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary PGI2 increased cAMP levels in cultured endothelial cells derived from bovine aortas in the presence of isobutylmethylxanthine (IBMX). Stable PGI analogues were more effective, while PGE1 was without effect. In cultured smooth muscle cells from bovine aortas, PGI2, PGE1 and the stable PGI analogues dose-dependently increased cAMP levels in the absence and presence of IBMX. The data confirm the stimulatory effect of PGI2 on cAMP content in bovine coronary artery rings and suggest that the effect is mainly due to the stimulatory action of PGI2 on cAMP in smooth muscle cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00500304
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