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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of nerve growth factor content in C6 glioma cells by β-adrenergic receptor stimulation (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 300 (1977), S. 123-129 
    Details
    ISSN: 1432-1912
    Keywords: Nerve growth factor ; C6 glioma cells ; Beta-catecholamine receptor ; Cyclic AMP ; Neuron-glia interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The C6 glioma cell line contains nerve growth factor (NGF) which can be released into the medium. Treatment of the cells with beta-adrenoceptor agonists resulted in increased content of NGF in both the cells and the medium within a few hours, whereas alpha-adrenoceptor agonists were ineffective. The response was blocked by beta- but not alpha-adrenoceptor antagonists. The increase of the NGF content of glioma cells appeared to be mediated by an elevation of cyclic AMP or GMP. The addition to the cell cultures of other putative neurotransmitters failed to change the content of either NGF or cyclic AMP. These results are discussed with respect to a model for adrenergic neuron-glial interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505042
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Altered Intermediate Filament Expression in Human Neuroblastoma Cells Transformed by a Growth-Promoting Agent Derived from Schizophrenic CSF (1997)
    Springer
    Cellular and molecular neurobiology 17 (1997), S. 1-11 
    Details
    ISSN: 1573-6830
    Keywords: vimentin ; neurofilament ; SK-N-SH(EP) ; neuroblastoma ; immunohistochemistry ; Western blot ; schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. Transformed (TR) cell lines showed faster doubling times and higher cell densities at confluence, as well as altered morphology, changing from flat epitheloid to smaller round or bipolar shapes. Since such morphological changes are suggestive of alterations in intermediate filaments, we have analyzed the expression of both vimentin and neurofilament. 2. Immunohistochemical analysis of vimentin showed a redistribution from a cytoplasmic network to a perinuclear accumulation in TR cell lines. 3. Western blot analysis demonstrated that the vimentin content was decreased 60–90%. The content of the 70-kD neurofilament protein was also decreased in TR cells, but its intracellular distribution was indistinguishable from that in the control cell lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026320919282
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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