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Dopamine- and apomorphine-sensitive adenylate cyclase in homogenates of rabbit retina (1975)

Bucher, M. -B. ; Schorderet, M.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 288 (1975), S. 103-107

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ISSN: 1432-1912

Keywords: Dopamine ; Apomorphine ; Cyclic AMP ; Retina-Receptor

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Dopamine (0.5–100 μM) as well as apomorphine (1–100 μM) were found to be potent stimulators of adenylate cyclase in homogenates of rabbit retina. When compared with the dopamine-effect at 10 μM, half-stimulation was also obtained in response to noradrenaline or adrenaline, whereas isoprenaline or phenylephrine were ineffective. Furthermore, the dopamine-induced production of cyclic AMP was blocked by chloropromazine and haloperidol. These data would suggest the occurence of a specific “dopamine receptor” in the retina of the rabbit.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00501818

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