ISSN:
1432-0584
Keywords:
Key words Itraconazole
;
Vinca alkaloids
;
Neurotoxicity
;
MDR
;
Cytochrome P-450
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In four of 14 patients with acute lymphoblastic leukemia (ALL) who received induction chemotherapy containing weekly injections of vincristine and simultaneous antifungal prophylaxis with itraconazole, unusually severe and early vincristine-induced neurotoxicity was observed. In these patients (three female, one male) paresthesia and muscle weakness of the upper/lower extremities and paralytic ileus occurred after the first or second vincristine injection. In one patient a laryngeal nerve paresis required mechanical ventilation. The neurotoxic complications were more serious than those seen in a previous series of 460 ALL patients under the identical cytostatic regimen but without itraconazole prophylaxis. The underlying mechanism is unclear. Interaction with the cytochrome P-450 system, reversal of multidrug resistance, and influence of estrogens are to be considered.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01697985
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