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  • Cytogenetics  (1)
  • Glycoprotein  (1)
  • Tissue culture  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Characteristics of rhabdomyosarcoma cell lines derived from uterine carcinosarcomas (1997)
    Springer
    Virchows Archiv 431 (1997), S. 249-256 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Key words Malignant mixed müllerian tumour ; Carcinosarcoma ; Rhabdomyosarcoma ; Tissue culture ; Cytogenetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Rhabdomyosarcoma (RMS) is occasionally found in the female genital tract, and mostly appears as one of the heterologous mesenchymal components in uterine carcinosarcoma designated as malignant mixed müllerian tumour (MMMT). We examined the biological properties of a pure rhabdomyosarcoma (RMS) cell line designated FU-MMT-3, which was newly established from a surgical specimen taken from a patient with uterine MMMT. We also evaluated c-myc and MYCN gene amplification in three RMS cell lines (including FU-MMT-3) derived from three MMMTs by Southern blot analysis. FU-MMT-3 cells were propagated continuously for 57 serial passages over a 2-year period in vitro. FU-MMT-3 was able to produce tumours demonstrating pure RMS in athymic nude mice. Cytogenetically, FU-MMT-3 showed a triploidy pattern, with complex karyotypic abnormalities including trisomy of chromosome 8. All three RMS cell lines, including FU-MMT-3, showed amplification of the c-myc gene (approximately fourfold to eightfold), while no cell lines demonstrated MYCN gene amplification. FU-MMT-3 is considered to provide a useful system for the study of the biological behaviour of RMS in MMMTs. Extra copies of chromosome 8 and c-myc gene amplification may be associated with the rhabdomyoblastic differentiation in MMMT.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004280050096
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  • 2
    Digitale Medien
    Digitale Medien
    Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family (2000)
    Springer
    Journal of human genetics 45 (2000), S. 378-382 
    Details
    ISSN: 1435-232X
    Schlagwort(e): Key words SIRP ; SHPS-1 ; Glycoprotein ; Chromosome 20p13 ; RH mapping
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-β, suggesting that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s100380070013
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