ISSN:
1432-1238
Keywords:
Key words Macrophage inflammatory protein-1alpha (MIP-1α)
;
Interleukin-8 (IL-8)
;
Sepsis
;
Disseminated intravascular Coagulation (DIC)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Description / Table of Contents:
Structured Abstract Objective: To determine the significance of the C–C chemokine MIP-1α and the C–X–C chemokine IL-8 in sepsis. Design: Prospective study. Setting: Clinical investigation, emergency department and general intensive care unit of university hospital. Patients and participants: 38 septic patients and 5 healthy volunteers were studied. Sepsis was diagnosed following the criteria formulated by ACCP/SCCM. Interventions: 10–20 ml of blood was drawn from each patient at the time of initial diagnosis of sepsis. Measurements and results: MIP-1α and IL-8 were determined by sandwich ELISA. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 was detected in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in patients with disseminated intravascular coagulation (DIC) (p〈0.05), central nervous system (CNS) dysfunction (p〈0.05), renal failure (p〈0.01) and the mortality rates were higher in the IL-8 detectable group than in the IL-8 undetectable group (50% vs 0%, p〈0.05). Conclusions: The production of MIP-1α and IL-8 was increased in sepsis. Furthermore, an initially detectable level of circulating IL-8, but not MIP-1α, predicted a high mortality in sepsis diagnosed according to the ACCP/SCCM criteria.
Notes:
Abstract We studied blood MIP-1α and IL-8 in 38 septic patients and 5 healthy volunteers. Both chemokines were undetectable in the healthy volunteers. In sepsis, serum MIP-1α was detected in 45% of the patients and IL-8 in 84%. The levels of MIP-1α, but not of IL-8, correlated with CRP, IL-6 and TNFα levels. Complications, including various organ failures and mortality, showed no correlation with serum MIP-1α levels. In contrast, we found increased levels of serum IL-8 in septic patients with disseminated intravascular coagulation, central nervous system (CNS) dysfunction or renal failure, and the mortality rate was higher in the IL-8-detectable group than in the IL-8 undetectable group (50% vs 0%, p〈0.05). In conclusion, the production of both MIP-1α and IL-8 was increased and initially detectable levels of circulating IL-8 predicted high mortality in sepsis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01709331
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